Multiple frequency functional connectivity in the hand somatosensory network: An EEG study
Multiple frequency functional connectivity in the hand somatosensory network: An EEG study
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手体感网络中的多频率功能连接：脑电图研究
DOI：
10.1016/j.clinph.2012.12.004
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发表时间：
2013
影响因子：
4.7
通讯作者：
F. Tecchio
中科院分区：
文献类型：
--
作者：
C. Porcaro;G. Coppola;F. Pierelli;S. Seri;G. Lorenzo;L. Tomasevic;C. Salustri;F. Tecchio
目的探讨初级体感觉神经网络内的通讯动态。方法记录6例健康受试者正中神经刺激引起的多通道脑电图反应。我们利用功能源分离（Functional Source Separation， FSS）算法，通过评估5个神经元节点（脑干、丘脑和3个初级感觉运动皮层）之间的部分定向相干性（PDC），研究了诱发反应的定向连通性。我们分别在低（1-200Hz， LF）和高（450-750Hz， HF）频率范围内分析了方向连通性。结果slf前向连通性在刺激后16、20、30和50ms出现峰值。连接强度的估计是通过涉及皮质和皮质下节点的反馈来调节的。在HF中，前向连通性在20ms、30ms和50ms处出现峰值，没有明显的反馈相关强度变化。在这一首次人类非侵入性研究中，我们记录了皮层下和皮层体感觉通路的定向连接，区分了LF和HF范围内的传输特性。意义FSS和PDC在一个简单的方案中联合使用，如正中神经刺激，揭示了体感诱发反应的高频和低频成分如何在功能上相互关联，以维持健康个体的体感知觉。因此，这些成分可能被潜在地作为病理条件的生物标志物进行探索。
OBJECTIVETo investigate the dynamics of communication within the primary somatosensory neuronal network.METHODSMultichannel EEG responses evoked by median nerve stimulation were recorded from six healthy participants. We investigated the directional connectivity of the evoked responses by assessing the Partial Directed Coherence (PDC) among five neuronal nodes (brainstem, thalamus and three in the primary sensorimotor cortex), which had been identified by using the Functional Source Separation (FSS) algorithm. We analyzed directional connectivity separately in the low (1–200Hz, LF) and high (450–750Hz, HF) frequency ranges.RESULTSLF forward connectivity showed peaks at 16, 20, 30 and 50ms post-stimulus. An estimate of the strength of connectivity was modulated by feedback involving cortical and subcortical nodes. In HF, forward connectivity showed peaks at 20, 30 and 50ms, with no apparent feedback-related strength changes.CONCLUSIONSIn this first non-invasive study in humans, we documented directional connectivity across subcortical and cortical somatosensory pathway, discriminating transmission properties within LF and HF ranges.SIGNIFICANCEThe combined use of FSS and PDC in a simple protocol such as median nerve stimulation sheds light on how high and low frequency components of the somatosensory evoked response are functionally interrelated in sustaining somatosensory perception in healthy individuals. Thus, these components may potentially be explored as biomarkers of pathological conditions.
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影响因子：
2.5
作者：
Ikeda, H;Leyba, L;Okada, YC
通讯作者：
Okada, YC
影响因子：
0.9
作者：
Nicolelis,MA;Chapin,JK;Lin,CS
通讯作者：
Lin,CS
影响因子：
2.5
作者：
Jones, MS;MacDonald, KD;Barth, DS
通讯作者：
Barth, DS
DOI：
10.1073/pnas.94.2.724
发表时间：
1997-01-21
影响因子：
11.1
作者：
Pedroarena, C;Llinas, R
通讯作者：
Llinas, R