Drugs that prevent mouse sleep also block light-induced locomotor suppression, circadian rhythm phase shifts and the drop in core temperature.
Drugs that prevent mouse sleep also block light-induced locomotor suppression, circadian rhythm phase shifts and the drop in core temperature.
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DOI：
10.1016/j.neuroscience.2013.09.025
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发表时间：
2013-12-19
期刊：
影响因子：
3.3
通讯作者：
Morin LP
中科院分区：
文献类型：
--
作者：
Vivanco P;Studholme KM;Morin LP
小鼠在夜间活动阶段暴露于短暂的光刺激会诱发多种同时发生的行为或生理反应，包括昼夜节律相移、核心体温 (Tc) 下降、运动活动和睡眠抑制。每个反应都是由光触发的，持续相对固定的时间间隔，并且不需要额外的光来表达。目前的研究涉及精神兴奋药物、甲基苯丙胺 (MA)、莫达非尼 (MOD) 或咖啡因 (CAF) 改变光诱导反应的能力。在 CT11 将药物或载体 (VEH) 注射到持续黑暗饲养的小鼠中，然后在 CT13 暴露于 5 分钟 100 μW/cm2 光或无光。对照（VEH/Light）显示大约 60 分钟的相位延迟。相比之下，每种药物的反应均显着减弱（仅延迟 12-15 分钟）。在 LD12:12 光周期下，VEH/光处理的小鼠 Tc 下降约 1.3 °C，同时伴有运动抑制，并且这两种效应均被药物预处理消除。每种药物在注射后间隔期间都会提高活性，但也有证据表明在光测试刺激之前 CAF 在黑暗中引起的活性减退。 CAF 的 Tc 急剧升高； MA 急剧降低了 Tc，但两种药物都降低了早期黑暗期间的 Tc (ZT12.5-ZT13)。精神兴奋药物阻断光暴露的多种影响的能力并不是药物引起的多动症的结果。研究结果提出了关于药物、活动、睡眠和 Tc 如何影响对光的行为和生理反应的问题。
Exposure of mice to a brief light stimulus during their nocturnal active phase induces several simultaneous behavioral or physiological responses, including circadian rhythm phase shifts, a drop in core body temperature (Tc), suppression of locomotor activity and sleep. Each response is triggered by light, endures for a relatively fixed interval and does not require additional light for expression. The present studies address the ability of the psychostimulant drugs, methamphetamine (MA), modafinil (MOD) or caffeine (CAF), to modify the light-induced responses. Drug or vehicle (VEH) was injected at CT11 into constant dark-housed mice then exposed to 5 min 100 μW/cm2 light or no light at CT13. Controls (VEH/Light) showed approximately 60 min phase delays. In contrast, response was substantially attenuated by each drug (only 12-15 min delays). Under a LD12:12 photoperiod, VEH/light-treated mice experienced a Tc drop of about 1.3 °C coincident with locomotor suppression and both effects were abolished by drug pretreatment. Each drug elevated activity during the post-injection interval, but there was also evidence for CAF-induced hypoactivity in the dark prior to the photic test stimulus. CAF acutely elevated Tc; MA acutely lowered it, but both drugs reduced Tc during the early dark (ZT12.5-ZT13). The ability of the psychostimulant drugs to block the several effects of light exposure is not the result of drug-induced hyperactivity. The results raise questions concerning the manner in which drugs, activity, sleep and Tc influence behavioral and physiological responses to light.
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影响因子：
3.3
作者：
Edelstein, K;De La Iglesia, HO;Mrosovsky, N
通讯作者：
Mrosovsky, N
影响因子：
2.9
作者：
Mistlberger, RE;Antle, MC
通讯作者：
Antle, MC
影响因子：
25
作者：
Huang, ZL;Qu, WM;Hayaishi, O
通讯作者：
Hayaishi, O
DOI：
10.1523/jneurosci.6730-10.2011
发表时间：
2011-07-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lazarus M;Shen HY;Cherasse Y;Qu WM;Huang ZL;Bass CE;Winsky-Sommerer R;Semba K;Fredholm BB;Boison D;Hayaishi O;Urade Y;Chen JF
通讯作者：
Chen JF
影响因子：
3.3
作者：
Gallopin, T;Luppi, PH;Fort, P
通讯作者：
Fort, P