Tunnel conductance of Watson-Crick nucleoside-base pairs from telegraph noise.
Tunnel conductance of Watson-Crick nucleoside-base pairs from telegraph noise.
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DOI：
10.1088/0957-4484/20/18/185102
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发表时间：
2009-05-06
期刊：
影响因子：
3.5
通讯作者：
Lindsay S
中科院分区：
文献类型：
--
作者：
Chang S;He J;Lin L;Zhang P;Liang F;Young M;Huang S;Lindsay S
The use of tunneling signals to sequence DNA is presently hampered by the small tunnel conductance of a junction spanning an entire DNA molecule. The design of a readout system that uses a shorter tunneling path requires knowledge of the absolute conductance across base-pairs. We have exploited the stochastic switching of hydrogen-bonded DNA base-nucleoside pairs trapped in a tunnel junction to determine the conductance of individual molecular pairs. This conductance is found to be sensitive to the geometry of the junction, but a subset of the data appears to come from unstrained molecular pairs. The conductances determined from these pairs are within a factor two of the predictions of density functional calculations. The experimental data reproduces the counterintuitive theoretical prediction that guanine-deoxycytidine pairs (3 H-bonds) have a smaller conductance than adenine-thymine pairs (2 H-bonds). A bimodal distribution of switching lifetimes shows that both H-bonds and molecule-metal contacts break.
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