Intervention to lower household wood smoke exposure in Guatemala reduces ST-segment depression on electrocardiograms.
Intervention to lower household wood smoke exposure in Guatemala reduces ST-segment depression on electrocardiograms.
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DOI：
10.1289/ehp.1002834
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发表时间：
2011-11
影响因子：
10.4
通讯作者：
Schwartz J
中科院分区：
文献类型：
--
作者：
McCracken J;Smith KR;Stone P;Díaz A;Arana B;Schwartz J
背景资料：大量证据表明，细颗粒物（PM）空气污染是心血管疾病的原因之一，但对发展中国家家庭使用固体燃料造成的室内空气污染对心血管的影响知之甚少。室内污染和呼吸影响的随机暴露研究（英语：Randomized Exposure Study of Pollution Indoors and Respiratory Effects）是一项关于烟囱柴炉的随机试验，旨在减少木材烟雾暴露。目的：我们检验了炉子干预与明火使用相比会减少ST段压低并增加心率变异性（HRV）的假设。研究方法：我们使用了两种互补的研究设计：a）基于随机炉分配的组间比较，以及B）在试验期间使用明火并在试验后接受烟囱炉的对照受试者之间的前后比较。在49名38-84岁的干预组和70名对照组妇女中，持续20小时的心电图检查重复了3次，55名对照组妇女在接受炉灶后也进行了评估。每30分钟评估一次HRV和ST段值。ST段压低定义为平均值低于-1.00 mm。在每次心电图前测量个人细PM [空气动力学直径≤ 2.5 μm（PM2.5）]暴露24小时。结果：试验期间，对照组和干预组的PM2.5暴露均值分别为266和102 μg/m3。在试验期间，炉子干预与ST段压低的比值比为0.26（95%置信区间，0.08-0.90）相关。我们在前后对比中发现了类似的关联。干预与HRV无显著相关性。结论：炉灶干预与非特异性ST段压低的发生率降低相关，表明家庭木材烟雾暴露影响心室复极和潜在的心血管健康。
Background: A large body of evidence suggests that fine particulate matter (PM) air pollution is a cause of cardiovascular disease, but little is known in particular about the cardiovascular effects of indoor air pollution from household use of solid fuels in developing countries. RESPIRE (Randomized Exposure Study of Pollution Indoors and Respiratory Effects) was a randomized trial of a chimney woodstove that reduces wood smoke exposure. Objectives: We tested the hypotheses that the stove intervention, compared with open fire use, would reduce ST-segment depression and increase heart rate variability (HRV). Methods: We used two complementary study designs: a) between-groups comparisons based on randomized stove assignment, and b) before-and-after comparisons within control subjects who used open fires during the trial and received chimney stoves after the trial. Electrocardiogram sessions that lasted 20 hr were repeated up to three times among 49 intervention and 70 control women 38–84 years of age, and 55 control subjects were also assessed after receiving stoves. HRV and ST-segment values were assessed for each 30-min period. ST-segment depression was defined as an average value below –1.00 mm. Personal fine PM [aerodynamic diameter ≤ 2.5 μm (PM2.5)] exposures were measured for 24 hr before each electrocardiogram. Results: PM2.5 exposure means were 266 and 102 μg/m3 during the trial period in the control and intervention groups, respectively. During the trial, the stove intervention was associated with an odds ratio of 0.26 (95% confidence interval, 0.08–0.90) for ST-segment depression. We found similar associations with the before-and-after comparison. The intervention was not significantly associated with HRV. Conclusions: The stove intervention was associated with reduced occurrence of nonspecific ST-segment depression, suggesting that household wood smoke exposures affect ventricular repolarization and potentially cardiovascular health.
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影响因子：
10.4
作者：
Gold DR;Litonjua AA;Zanobetti A;Coull BA;Schwartz J;MacCallum G;Verrier RL;Nearing BD;Canner MJ;Suh H;Stone PH
通讯作者：
Stone PH
DOI：
10.1038/sj.jea.7500355
发表时间：
2004-04-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Bruce, N;McCracken, J;West, C
通讯作者：
West, C
DOI：
10.1164/rccm.200611-1627oc
发表时间：
2007-08-15
影响因子：
24.7
作者：
Chuang, Kai-Jen;Chan, Chang-Chuan;Tang, Chin-Sheng
通讯作者：
Tang, Chin-Sheng
影响因子：
37.8
作者：
Park, Sung Kyun;O'Neill, Marie S.;Schwartz, Joel
通讯作者：
Schwartz, Joel
影响因子：
3.8
作者：
Ghelfi, Elisa;Ramos-Rhoden, Claudia;Gonzalez-Flecha, Beatriz
通讯作者：
Gonzalez-Flecha, Beatriz