Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease.
Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease.
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PTPN 22同种异型对健康和疾病中天然和适应性免疫功能的影响
DOI：
10.3389/fimmu.2021.636618
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发表时间：
2021
影响因子：
7.3
通讯作者：
Mathews CE
中科院分区：
文献类型：
--
作者：
Armitage LH;Wallet MA;Mathews CE
蛋白酪氨酸磷酸酶，非受体22型（PTPN 22）调节一系列白细胞信号传导途径。PTPN 22中的单核苷酸多态性（SNP）rs2476601与1型糖尿病（T1D）和其他自身免疫性疾病的风险增加相关。在过去的十年中，PTPN 22在T细胞受体（TCR）和B细胞受体（BCR）信号传导中被深入研究。然而，次要等位基因对TCR信号传导中PTPN 22功能的影响是有争议的，一些报道认为它具有增强的功能并钝化TCR信号传导，而其他报道则认为它具有降低的功能并增加TCR信号传导。最近，在单核细胞、巨噬细胞、树突状细胞和中性粒细胞中检查了PTPN 22的核心功能以及PTPN 22的自身免疫相关变体等位基因赋予的功能紊乱。在这篇综述中，我们将讨论PTPN22在人类细胞中的已知功能，并详细说明自身免疫相关变体如何影响表达PTPN22的免疫细胞的功能。此外，我们考虑了目前尚未解决的问题，这些问题需要澄清PTPN 22在免疫细胞功能中的作用。
Protein tyrosine phosphatase, non-receptor type 22 (PTPN22) regulates a panoply of leukocyte signaling pathways. A single nucleotide polymorphism (SNP) in PTPN22, rs2476601, is associated with increased risk of Type 1 Diabetes (T1D) and other autoimmune diseases. Over the past decade PTPN22 has been studied intensely in T cell receptor (TCR) and B cell receptor (BCR) signaling. However, the effect of the minor allele on PTPN22 function in TCR signaling is controversial with some reports concluding it has enhanced function and blunts TCR signaling and others reporting it has reduced function and increases TCR signaling. More recently, the core function of PTPN22 as well as functional derangements imparted by the autoimmunity-associated variant allele of PTPN22 have been examined in monocytes, macrophages, dendritic cells, and neutrophils. In this review we will discuss the known functions of PTPN22 in human cells, and we will elaborate on how autoimmunity-associated variants influence these functions across the panoply of immune cells that express PTPN22. Further, we consider currently unresolved questions that require clarification on the role of PTPN22 in immune cell function.
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影响因子：
30.8
作者：
Barrett, Jeffrey C.;Clayton, David G.;Concannon, Patrick;Akolkar, Beena;Cooper, Jason D.;Erlich, Henry A.;Julier, Cecile;Morahan, Grant;Nerup, Jorn;Nierras, Concepcion;Plagnol, Vincent;Pociot, Flemming;Schuilenburg, Helen;Smyth, Deborah J.;Stevens, Helen;Todd, John A.;Walker, Neil M.;Rich, Stephen S.
通讯作者：
Rich, Stephen S.
DOI：
10.1073/pnas.0902745106
发表时间：
2009-04-28
影响因子：
11.1
作者：
Ben-Sasson, Shlomo Z.;Hu-Li, Jane;Paul, William E.
通讯作者：
Paul, William E.
影响因子：
4.4
作者：
Chang, Hui-Hsin;Miaw, Shi-Chuen;Ho, I-Cheng
通讯作者：
Ho, I-Cheng
DOI：
10.4049/jimmunol.0713370
发表时间：
2009-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Arechiga AF;Habib T;He Y;Zhang X;Zhang ZY;Funk A;Buckner JH
通讯作者：
Buckner JH
影响因子：
3.7
作者：
Chang HH;Tai TS;Lu B;Iannaccone C;Cernadas M;Weinblatt M;Shadick N;Miaw SC;Ho IC
通讯作者：
Ho IC