Social influences on morphine-conditioned place preference in adolescent BALB/cJ and C57BL/6J mice.
Social influences on morphine-conditioned place preference in adolescent BALB/cJ and C57BL/6J mice.
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DOI：
10.1007/s00213-011-2421-2
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发表时间：
2012-02
影响因子：
3.4
通讯作者：
Lahvis, Garet P.
中科院分区：
文献类型：
--
作者：
Kennedy, Bruce C.;Panksepp, Jules B.;Runckel, Petra A.;Lahvis, Garet P.
在人类青少年中，药物使用在很大程度上受到同龄人的态度和行为的影响。社会因素也影响实验动物的觅药行为。条件性位置偏好（CPP）实验表明，社会背景可以影响啮齿动物从药物滥用中获得奖励体验的程度。然而，社会因素改变青少年啮齿动物药物奖励的确切方式仍然未知。我们采用了相对反社会的BALB/cJ（BALB）小鼠品系和更亲社会的C57 BL/6 J（B6）品系，以探讨是否“低”或“高”的动机与同龄人的影响，社会背景对吗啡CPP（MCPP）的影响。通过皮下注射硫酸吗啡（0.25、1.0或5.0 mg/kg）使青春期小鼠适应。在MCPP程序期间，将小鼠隔离（Ih）或在社会群体（Sh）内饲养。类似地，在注射后，使小鼠单独适应（Ic）或在社会群体内适应（Sc）。青少年B6小鼠表达了强大的MCPP响应，除了当受到Ih-Sc，这表明，隔离后，高水平的社会动机的小鼠不太容易受到奖励性质的吗啡时，他们在社会群体中的条件。相比之下，MCPP反应的BALB小鼠是最敏感的吗啡条件时，受试者经历了变化，他们的社会环境之间的住房和空调（IH-Sc或SH-IC）。我们的研究结果表明，青春期小鼠对吗啡诱导奖励的易感性受到社会背景和社会动机遗传差异之间复杂相互作用的调节。
Among human adolescents, drug use is substantially influenced by the attitudes and behaviors of peers. Social factors also affect the drug-seeking behaviors of laboratory animals. Conditioned place preference (CPP) experiments indicate that social context can influence the degree to which rodents derive a rewarding experience from drugs of abuse. However, the precise manner by which social factors alter drug reward in adolescent rodents remains unknown. We employed the relatively asocial BALB/cJ (BALB) mouse strain and the more prosocial C57BL/6J (B6) strain to explore whether “low” or “high” motivation to be with peers influences the effects of social context on morphine CPP (MCPP). Adolescent mice were conditioned by subcutaneous injections of morphine sulfate (0.25, 1.0, or 5.0 mg/kg). During the MCPP procedure, mice were housed in either isolation (Ih) or within a social group (Sh). Similarly, following injection, mice were conditioned either alone (Ic) or within a social group (Sc). Adolescent B6 mice expressed a robust MCPP response except when subjected to Ih-Sc, which indicates that, following isolation, mice with high levels of social motivation are less susceptible to the rewarding properties of morphine when they are conditioned in a social group. By contrast, MCPP responses of BALB mice were most sensitive to morphine conditioning when subjects experienced a change in their social environment between housing and conditioning (Ih–Sc or Sh–Ic). Our findings demonstrate that susceptibility to morphine-induced reward in adolescent mice is moderated by a complex interaction between social context and heritable differences in social motivation.
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影响因子：
1.6
作者：
Hodgson SR;Hofford RS;Roberts KW;Wellman PJ;Eitan S
通讯作者：
Eitan S
DOI：
10.1007/978-1-60761-934-5_6
发表时间：
2011-01-01
期刊：
ANIMAL MODELS OF DRUG ADDICTION
影响因子：
--
作者：
Cunningham, Christopher L.;Groblewski, Peter A.;Voorhees, Charlene M.
通讯作者：
Voorhees, Charlene M.
影响因子：
3.6
作者：
BORLONGAN, CV;WATANABE, S
通讯作者：
WATANABE, S
影响因子：
1.3
作者：
Peterson, Christina;Buser, Trevor;Westburg, Nancy
通讯作者：
Westburg, Nancy
影响因子：
2.9
作者：
BERNARD, BK;FINKELSTEIN, ER;EVERETT, GM
通讯作者：
EVERETT, GM