Applications of Electrospinning for Tissue Engineering in Otolaryngology.
Applications of Electrospinning for Tissue Engineering in Otolaryngology.
复制标题
DOI：
10.1177/0003489420959692
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Chiang T
中科院分区：
文献类型：
--
作者：
Heilingoetter A;Smith S;Malhotra P;Johnson J;Chiang T
在组织工程中，生物材料为细胞与细胞的粘附、增殖和组织形成创造了3D支架。由于其与细胞外基质的相似性和结构适应性，纳米纤维在组织工程中特别令人感兴趣。静电纺丝是一种用于制备组织工程支架的良好记录技术。在这里，我们提出的文献中的应用静电纺丝领域的耳鼻喉科。进行PubMed数据库检索，以分离关于电纺纳米纤维在耳鼻喉科组织工程中的应用的已发表文章。获得了每项研究的研究设计、尺寸、试验材料、头颈部内的应用部位和结局。几乎所有关于耳鼻喉科电纺的数据都是在过去6年中发表的（84%），突出了其新奇。共确定了25项临床前研究：9项体外研究、5项体内动物研究和11项联合研究。应用地点包括：气管重建16例，鼓膜修补3例，颅神经再生3例，乳突成骨1例，耳鼻软骨形成2例。组织工程是一个新兴的领域，最近在耳鼻喉科领域的创新应用。静电纺丝纳米纤维特别地在耳鼻喉科领域中具有相关应用，部分地由于它们与天然细胞外基质的相似性，其中新兴的感兴趣领域是鼓膜修复、颅神经再生和气管重建。
In tissue engineering, biomaterials create a 3D scaffold for cell-to-cell adhesion, proliferation and tissue formation. Because of their similarity to extracellular matrix and architectural adaptability, nanofibers are of particular interest in tissue engineering. Electrospinning is a well-documented technique for nanofiber production for tissue engineering scaffolds. Here we present literature on the applications of electrospinning in the field of otolaryngology. A PubMed database search was performed to isolate articles published about applications of electrospun nanofibers for tissue engineering in otolaryngology. Study design, size, material tested, site of application within the head and neck, and outcomes were obtained for each study. Almost all data on electrospinning in otolaryngology was published in the last 6 years (84%), highlighting its novelty. A total of 25 pre-clinical studies were identified: 9 in vitro studies, 5 in vivo animal studies, and 11 combination studies. Sites of application included: tracheal reconstruction (n = 16), tympanic membrane repair (n = 3), cranial nerve regeneration (n = 3), mastoid osteogenesis (n = 1) and ear/nose chondrogenesis (n = 2). Tissue engineering is a burgeoning field, with recent innovative applications in the field of otolaryngology. Electrospun nanofibers specifically have relevant applications in the field of otolaryngology, due in part to their similarity to native extracellular matrix, with emerging areas of interest being tympanic membrane repair, cranial nerve regeneration and tracheal reconstruction.
登录
查看更多内容
影响因子：
3.1
作者：
Weng L;Xie J
通讯作者：
Xie J
DOI：
10.1016/j.ijbiomac.2016.04.031
发表时间：
2016-12-01
影响因子：
8.2
作者：
Jang, Chul Ho;Lee, Hyeongjin;Kim, GeunHyung
通讯作者：
Kim, GeunHyung
影响因子：
2.1
作者：
Hu, Aijun;Zuo, Baoqi;Lan, Qing
通讯作者：
Lan, Qing
影响因子：
1.4
作者：
Dharmadhikari, Sayali;Best, Cameron A.;Chiang, Tendy
通讯作者：
Chiang, Tendy
影响因子：
3.4
作者：
Pepper, Victoria;Best, Cameron A.;Chiang, Tendy
通讯作者：
Chiang, Tendy