Convergent processing of both positive and negative motivational signals by the VTA dopamine neuronal populations.
Convergent processing of both positive and negative motivational signals by the VTA dopamine neuronal populations.
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DOI：
10.1371/journal.pone.0017047
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发表时间：
2011-02-15
期刊：
影响因子：
3.7
通讯作者：
Tsien JZ
中科院分区：
文献类型：
--
作者：
Wang DV;Tsien JZ
传统上研究腹侧被盖区(VTA)的多巴胺神经元在奖赏相关的动机或药物成瘾中所起的作用。在这里，我们研究了VTA多巴胺神经元群体如何处理自由行为小鼠的恐惧和负面经历以及奖励信息。使用多路四极管记录，我们发现，在预测食物奖励的条件性音调中，多达%的多巴胺神经元表现出显著的激活，而同样数量的多巴胺神经元也对自由落体和震动事件等恐惧体验做出反应。这些VTA推测的多巴胺神经元中的大多数表现出抑制和偏移-反弹兴奋，而∼25%的推测的多巴胺神经元表现出由恐惧事件引起的兴奋。重要的是，VTA推测的多巴胺神经元表现出参数编码特性：它们的放电变化持续时间与恐惧事件的持续时间成正比。此外，我们证明了语境信息对于这些神经元通过相同的条件音调分别引起积极或消极的动机反应是至关重要的。综上所述，我们的研究结果表明，VTA多巴胺神经元可能采用会聚编码策略来处理积极和消极的经验，并与线索和环境背景密切结合。
Dopamine neurons in the ventral tegmental area (VTA) have been traditionally studied for their roles in reward-related motivation or drug addiction. Here we study how the VTA dopamine neuron population may process fearful and negative experiences as well as reward information in freely behaving mice. Using multi-tetrode recording, we find that up to 89% of the putative dopamine neurons in the VTA exhibit significant activation in response to the conditioned tone that predict food reward, while the same dopamine neuron population also respond to the fearful experiences such as free fall and shake events. The majority of these VTA putative dopamine neurons exhibit suppression and offset-rebound excitation, whereas ∼25% of the recorded putative dopamine neurons show excitation by the fearful events. Importantly, VTA putative dopamine neurons exhibit parametric encoding properties: their firing change durations are proportional to the fearful event durations. In addition, we demonstrate that the contextual information is crucial for these neurons to respectively elicit positive or negative motivational responses by the same conditioned tone. Taken together, our findings suggest that VTA dopamine neurons may employ the convergent encoding strategy for processing both positive and negative experiences, intimately integrating with cues and environmental context.
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