Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces.
Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces.
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DOI：
10.1088/1741-2552/ac36e2
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发表时间：
2021-11-25
影响因子：
4
通讯作者：
Fallon JB
中科院分区：
文献类型：
--
作者：
Eiber CD;Payne SC;Biscola NP;Havton LA;Keast JR;Osborne PB;Fallon JB
内脏神经的神经调节正在被广泛地研究用于治疗各种疾病，但有效的翻译需要增加神经接口性能的有效性和可预测性。在这里，我们使用大鼠内脏神经的计算模型来预测神经解剖变异如何影响电刺激和使用实验性平面神经接口进行记录。我们开发了一种混合计算管道，内脏神经整体记录和刺激(Viners)，将细胞外电场的有限元模拟与单个轴突的生物物理模拟相结合。测量或从公开数据集中获得大鼠盆腔和迷走神经中束和轴突的解剖学特性。为了验证Viners，我们用一个实验性的四电极平面阵列模拟了盆神经刺激和记录。从骨盆神经测量的轴突直径被用来模拟有髓和无髓轴突的群体，并模拟电诱发单元场电位(SUFP)的记录。在不断增大的内脏神经束中，我们的模拟预测刺激阈值增加，SUFP幅度降低。模拟的阈值变化主要是神经膜厚度的变化，而外膜厚度与神经束直径相关。我们还证明了Viners可以模拟电诱发复合动作电位(ECAPs)的记录，这在性质上类似于用用于模拟的阵列进行的盆神经记录。我们引入Viners作为一种新的开源计算工具，用于模拟来自内脏神经的大规模刺激和记录。Viners用一个实验性的平面电极阵列预测了大鼠盆神经的神经解剖变异如何影响刺激和记录。我们展示了Viners可以模拟ECAPS来捕捉我们录音的特征，但我们的结果表明，潜在的神经元模型需要进一步改进和专门调整，以准确模拟内脏神经轴突。
Neuromodulation of visceral nerves is being intensively studied for treating a wide range of conditions, but effective translation requires increasing the efficacy and predictability of neural interface performance. Here we use computational models of rat visceral nerve to predict how neuroanatomical variability could affect both electrical stimulation and recording with an experimental planar neural interface. We developed a hybrid computational pipeline, Visceral Nerve Ensemble Recording & Stimulation (ViNERS), to couple finite-element modelling of extracellular electrical fields with biophysical simulations of individual axons. Anatomical properties of fascicles and axons in rat pelvic and vagus nerves were measured or obtained from public datasets. To validate ViNERS, we simulated pelvic nerve stimulation and recording with an experimental four-electrode planar array. Axon diameters measured from pelvic nerve were used to model a population of myelinated and unmyelinated axons and simulate recordings of electrically evoked single-unit field potentials (SUFPs). Across visceral nerve fascicles of increasing size, our simulations predicted an increase in stimulation threshold and a decrease in SUFP amplitude. Simulated threshold changes were dominated by changes in perineurium thickness, which correlates with fascicle diameter. We also demonstrated that ViNERS could simulate recordings of electrically-evoked compound action potentials (ECAPs) that were qualitatively similar to pelvic nerve recording made with the array used for simulation. We introduce ViNERS as a new open-source computational tool for modelling large-scale stimulation and recording from visceral nerves. ViNERS predicts how neuroanatomical variation in rat pelvic nerve affects stimulation and recording with an experimental planar electrode array. We show ViNERS can simulate ECAPS that capture features of our recordings, but our results suggest the underlying NEURON models need to be further refined and specifically adapted to accurately simulate visceral nerve axons.
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DOI：
10.1007/bf01159386
发表时间：
1983-01-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
BERTHOLD, CH;RYDMARK, M
通讯作者：
RYDMARK, M
影响因子：
--
作者：
Chen, Yongsheng;Haacke, E Mark;Li, Jun
通讯作者：
Li, Jun
影响因子：
5.1
作者：
Christie, Breanne P.;Freeberg, Max;Triolo, Ronald J.
通讯作者：
Triolo, Ronald J.
影响因子：
1.2
作者：
Gaines, Jessica L.;Finn, Kathleen E.;Polasek, Katharine H.
通讯作者：
Polasek, Katharine H.
影响因子：
4.6
作者：
Casciola M;Xiao S;Pakhomov AG
通讯作者：
Pakhomov AG