Photothermally enhanced drug delivery by ultrasmall multifunctional FeCo/graphitic shell nanocrystals.
Photothermally enhanced drug delivery by ultrasmall multifunctional FeCo/graphitic shell nanocrystals.
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DOI：
10.1021/nn103415x
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发表时间：
2011-02-22
期刊：
影响因子：
17.1
通讯作者：
Dai H
中科院分区：
文献类型：
--
作者：
Sherlock SP;Tabakman SM;Xie L;Dai H
合成了具有超高磁化强度的FeCo/石墨碳壳（FeCo/GC）纳米晶体（直径~4 ~ 5 nm），并将其功能化，发展成为多功能生物相容性材料。我们证明了这种材料作为联合药物输送、近红外（NIR）光热治疗和体外磁共振成像（MRI）的综合系统的能力。通过在石墨壳上π堆积，我们发现了高效负载阿霉素（DOX）的方法，以提供FeCo/GC-DOX配合物，并从颗粒中释放pH敏感的DOX。我们观察到FeCo/GC-DOX在近红外激光（808 nm）诱导的43°C高温下20分钟的细胞内药物递送增强，导致FeCo/GC-DOX对乳腺癌细胞的毒性显著增加。光热加热下FeCo/GC-DOX药物递送对癌细胞的协同杀伤作用是由于43℃高温条件下癌细胞对FeCo/GC-DOX复合物的摄取增强了2倍，DOX毒性增加。协同近红外光热增强药物传递和MRI与FeCo/GC纳米晶体的结合可能导致生物医学检测和治疗的强大的多模态系统。
FeCo/graphitic carbon shell (FeCo/GC) nanocrystals (~4-5 nm in diameter) with ultra-high magnetization are synthesized, functionalized and developed into multifunctional biocompatible materials. We demonstrate the ability of this material to serve as an integrated system for combined drug delivery, near-infrared (NIR) photothermal therapy and magnetic resonance imaging (MRI) in-vitro. We show highly efficient loading of doxorubicin (DOX) by π-stacking on the graphitic shell to afford FeCo/GC-DOX complexes and pH sensitive DOX release from the particles. We observe enhanced intracellular drug delivery by FeCo/GC-DOX under 20 minutes of near-infrared (NIR) laser (808 nm) induced hyperthermia to 43°C, resulting in a significant increase of FeCo/GC-DOX toxicity towards breast cancer cells. The synergistic cancer cell killing by FeCo/GC-DOX drug delivery under photothermal heating is due to a ~2-fold enhancement of cancer cell uptake of FeCo/GC-DOX complex and the increased DOX toxicity under the 43°C hyperthermic condition. The combination of synergistic NIR photothermally enhanced drug delivery and MRI with the FeCo/GC nanocrystals could lead to a powerful multimodal system for biomedical detection and therapy.
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影响因子：
29.4
作者：
Park, Ji-Ho;von Maltzahn, Geoffrey;Ong, Luvena L.;Centrone, Andrea;Hatton, T. Alan;Ruoslahti, Erkki;Bhatia, Sangeeta N.;Sailor, Michael J.
通讯作者：
Sailor, Michael J.
影响因子：
17.1
作者：
Park, Huiyul;Yang, Jaemoon;Yoo, Kyung-Hwa
通讯作者：
Yoo, Kyung-Hwa
影响因子：
15
作者：
Kam, NWS;Dai, HJ
通讯作者：
Dai, HJ
影响因子：
41.2
作者：
Seo, Won Seok;Lee, Jin Hyung;Dai, Hongjie
通讯作者：
Dai, Hongjie
影响因子：
4.7
作者：
Derfus, Austin M.;Chen, Alice A.;Bhatia, Sangeeta N.
通讯作者：
Bhatia, Sangeeta N.