Serum insulin-like growth factor-1, asthma, and lung function among British adults.
Serum insulin-like growth factor-1, asthma, and lung function among British adults.
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DOI：
10.1016/j.anai.2020.12.005
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Celedón JC
中科院分区：
文献类型：
--
作者：
Han YY;Yan Q;Chen W;Forno E;Celedón JC
胰岛素样生长因子-1（IGF-1）在代谢综合征（MS）的发病机制中起关键作用，而MS又与哮喘相关。IGF-1是否有助于哮喘病因或哮喘严重程度在很大程度上是未知的。探讨成人血清IGF-1与哮喘、哮喘转归及肺功能的关系。对297，590名成年人（年龄40-69岁）进行的横断面研究，他们参加了英国生物银行，没有诊断出糖尿病，也没有使用胰岛素。采用多变量logistic或线性回归分析血清IGF-1与医生诊断的哮喘、当前喘息、哮喘住院和肺功能测量（FEV 1、FVC和FEV 1 /FVC）。高于最低四分位数（Q1）的血清IGF-1水平与哮喘的低风险显著相关（第四分位数（Q4）与Q1的校正比值比[aOR]=0.88，95%置信区间[CI]=0.85-0.91）。在哮喘参与者中，IGF-1水平高于Q1与当前喘息的几率较低显著相关（Q4与Q1的aOR =0.89，95%CI =0.83-0.96），但与哮喘住院无关。血清IGF-1与FEV 1（B=20.9 mL，95%CI=19.1-22.7）和FVC（B=25.6 mL，95%CI=23.4-27.7）显著正相关，与哮喘诊断无关;这些相关性在男性和女性中均显著，男性的估计影响更大。在一项针对英国成年人的大型研究中，较高的血清IGF-1水平与较低的哮喘和当前喘息的几率以及较高的FEV 1和FVC相关。我们的研究结果表明，循环IGF-1对成人哮喘和哮喘结局具有潜在的有益作用。
Insulin-like growth factor-1 (IGF-1) plays a key role in the pathogenesis of metabolic syndrome (MS), which is in turn associated with asthma. Whether IGF-1 contributes to asthma causation or asthma severity is largely unknown. To examine the relation between serum IGF-1 and asthma, asthma outcomes, and lung function in adults. Cross-sectional study of 297,590 adults (aged 40–69 years) who participated in the United Kingdom Biobank, had no diagnosis of diabetes, and were not on insulin. Multivariable logistic or linear regression was used to analyze serum IGF-1 and physician-diagnosed asthma, current wheeze, asthma hospitalizations, and lung function measures (FEV 1, FVC and FEV 1 /FVC). Serum IGF-1 levels above the lowest quartile (Q1) were significantly associated with lower odds of asthma (adjusted odds ratio [aOR] for fourth quartile (Q4) vs. Q1=0.88, 95% confidence interval [CI]=0.85–0.91). Among participants with asthma, IGF-1 levels above Q1 were significantly associated with lower odds of current wheeze (aOR for Q4 vs. Q1=0.89, 95% CI=0.83–0.96), but not with asthma hospitalizations. Serum IGF-1 was significantly and positively associated with FEV 1 (b=20.9 mL, 95%CI=19.1–22.7) and FVC (b=25.6 mL, 95%CI=23.4–27.7), regardless of an asthma diagnosis; these associations were significant in men and women, with larger estimated effects in men. In a large study of British adults, higher serum IGF-1 levels were associated with lower odds of asthma and current wheeze, and higher FEV 1 and FVC. Our findings suggest potential beneficial effects of circulating IGF-1 on asthma and asthma outcomes in adults.
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影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
癌症中的胰岛素样生长因子 (IGF) 通路靶向：IGF 轴的作用和未来组合研究的机会。
影响因子：
5.4
作者：
Simpson A;Petnga W;Macaulay VM;Weyer-Czernilofsky U;Bogenrieder T
通讯作者：
Bogenrieder T
影响因子：
4.6
作者：
Park S;Choi NK;Kim S;Lee CH
通讯作者：
Lee CH
DOI：
10.1183/20734735.000318
发表时间：
2018-06
期刊：
Breathe (Sheffield, England)
影响因子：
--
作者：
LoMauro A;Aliverti A
通讯作者：
Aliverti A
影响因子：
3.1
作者：
Gifford AH;Nymon AB;Ashare A
通讯作者：
Ashare A