Reward-Sensitive Basal Ganglia Stabilize the Maintenance of Goal-Relevant Neural Patterns in Adolescents.
Reward-Sensitive Basal Ganglia Stabilize the Maintenance of Goal-Relevant Neural Patterns in Adolescents.
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DOI：
10.1162/jocn_a_01572
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发表时间：
2020-08
影响因子：
3.2
通讯作者：
Gabrieli JDE
中科院分区：
文献类型：
--
作者：
Hubbard NA;Romeo RR;Grotzinger H;Giebler M;Imhof A;Bauer CCC;Gabrieli JDE
基底神经节（BG）和额顶叶回路的成熟与工作记忆（WM）的发育增益平行。神经生物学模型表明，成年WM性能增强奖励敏感BG和额顶叶区域之间的通信，通过增加稳定性，在维护目标相关的神经模式。目前尚不清楚这种奖励驱动的模式稳定性机制是否可能在WM的发展中发挥作用。在34个年轻的青少年（12.16-14.72岁）接受功能磁共振成像，奖励敏感的BG区域的本地化使用的激励加工任务。WM敏感区域的本地化使用延迟响应WM任务。功能连接分析被用来检查目标相关的功能连接模式的稳定性，在WM延迟期间之间和内部奖励敏感的BG和WM敏感的额顶叶区域。分析表明，更稳定的目标相关的连接模式之间的奖励敏感BG和WM敏感的额顶区与更大的青少年年龄和WM的能力。计算损伤模型还显示，从奖励敏感BG到WM敏感额顶叶区域的功能连接独特地增加了额顶叶区域内目标相关功能连接模式的稳定性。研究结果表明：（1）奖励-额顶脑回路中目标相关的交流模式的维持程度随着青少年的发育和工作记忆能力的提高而增加;（2）奖励敏感的BG到额顶脑区的交流增强了青少年工作记忆中目标相关神经模式的维持。奖赏驱动的目标相关神经模式稳定性的成熟可能为理解工作记忆的发展增强提供了一个假定的机制。
Maturation of basal ganglia (BG) and frontoparietal circuitry parallels developmental gains in working memory (WM). Neurobiological models posit that adult WM performance is enhanced by communication between reward-sensitive BG and frontoparietal regions, via increased stability in the maintenance of goal-relevant neural patterns. It is not known whether this reward-driven pattern stability mechanism may have a role in WM development. In 34 young adolescents (12.16–14.72 years old) undergoing fMRI, reward-sensitive BG regions were localized using an incentive processing task. WM-sensitive regions were localized using a delayed-response WM task. Functional connectivity analyses were used to examine the stability of goal-relevant functional connectivity patterns during WM delay periods between and within reward-sensitive BG and WM-sensitive frontoparietal regions. Analyses revealed that more stable goal-relevant connectivity patterns between reward-sensitive BG and WM-sensitive frontoparietal regions were associated with both greater adolescent age and WM ability. Computational lesion models also revealed that functional connections to WM-sensitive frontoparietal regions from reward-sensitive BG uniquely increased the stability of goal-relevant functional connectivity patterns within frontoparietal regions. Findings suggested (1) the extent to which goal-relevant communication patterns within reward-frontoparietal circuitry are maintained increases with adolescent development and WM ability and (2) communication from reward-sensitive BG to frontoparietal regions enhances the maintenance of goal-relevant neural patterns in adolescents’ WM. The maturation of reward-driven stability of goal-relevant neural patterns may provide a putative mechanism for understanding the developmental enhancement of WM.
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影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
4.6
作者：
De Asis-Cruz J;Bouyssi-Kobar M;Evangelou I;Vezina G;Limperopoulos C
通讯作者：
Limperopoulos C
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
影响因子：
3.2
作者：
Davidow, Juliet Y.;Sheridan, Margaret A.;Somerville, Leah H.
通讯作者：
Somerville, Leah H.
影响因子：
64.8
作者：
Albert, R;Jeong, H;Barabási, AL
通讯作者：
Barabási, AL