Habenula bibliometrics: Thematic development and research fronts of a resurgent field.

Habenula bibliometrics: Thematic development and research fronts of a resurgent field.
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DOI:
10.3389/fnint.2022.949162
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发表时间:
2022
影响因子:
3.5
通讯作者:
Su, Diansan
Su, Diansan
中科院分区:
医学3区
文献类型:
--
作者:
Chen, Sifan;Sun, Xiaoyu;Zhang, Yizhe;Mu, Yu;Su, Diansan

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habenula (Hb)是后间脑的一个小结构,在脊椎动物中高度保守,但直到过去二十年才引起相对较少的研究关注。神经行为研究表明,在广泛的动机和认知过程中,包括与精神疾病相关的功能,神经行为研究表明了关键功能,这激发了人们对神经行为的兴趣。Hb被广泛认为是通过调节大脑单胺能系统起作用的“反奖励”中心。然而,目前仍没有关于缰核研究的一般概念框架,也没有研究集中于揭示潜在的重要但被忽视的主题,这些主题可能会促进我们对生理功能的理解,或建议针对缰核的干预措施的潜在临床应用。利用科学制图工具,对2002 - 2021年从Web of science Core Collection (WoSCC)数据库中检索到的相关论文进行了定量和定性分析。在此,我们概述了与链链相关的出版物,揭示了主要的研究趋势,并通过补充文献计量分析优先考虑了一些关键的研究前沿。重点研究领域包括腹侧苍白球、伏隔核、尼古丁和MHb、GLT-1、斑马鱼和GCaMP、氯胺酮、深部脑刺激和GPR139。Hb的高度内在异质性,与后脑和前脑结构的广泛联系,以及与精神障碍的所有三个维度(内在化、外在化和精神病)的新兴联系表明,Hb可能是所有精神疾病共有的一种常见精神病理因素(称为p因素)的神经元底物。未来的挑战是在电路、细胞和分子水平上探索habenular调制的治疗潜力。
The habenula (Hb) is a small structure of the posterior diencephalon that is highly conserved across vertebrates but nonetheless has attracted relatively little research attention until the past two decades. The resurgent interest is motivated by neurobehavioral studies demonstrating critical functions in a broad spectrum of motivational and cognitive processes, including functions relevant to psychiatric diseases. The Hb is widely conceived as an “anti-reward” center that acts by regulating brain monoaminergic systems. However, there is still no general conceptual framework for habenula research, and no study has focused on uncovering potentially significant but overlooked topics that may advance our understanding of physiological functions or suggest potential clinical applications of Hb-targeted interventions. Using science mapping tools, we quantitatively and qualitatively analyzed the relevant publications retrieved from the Web of Science Core Collection (WoSCC) database from 2002 to 2021. Herein we present an overview of habenula-related publications, reveal primary research trends, and prioritize some key research fronts by complementary bibliometric analysis. High-priority research fronts include Ventral Pallidum, Nucleus Accumbens, Nicotine and MHb, GLT-1, Zebrafish, and GCaMP, Ketamine, Deep Brain Stimulation, and GPR139. The high intrinsic heterogeneity of the Hb, extensive connectivity with both hindbrain and forebrain structures, and emerging associations with all three dimensions of mental disorders (internalizing, externalizing, and psychosis) suggest that the Hb may be the neuronal substrate for a common psychopathology factor shared by all mental illnesses termed the p factor. A future challenge is to explore the therapeutic potential of habenular modulation at circuit, cellular, and molecular levels.
缰核:脊椎动物大脑中保守的不对称中继站。
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发表时间: 2009-04-12
影响因子: 6.3
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