Oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock.
Oxytocinergic cells of the posterior hypothalamic paraventricular nucleus participate in the food entrained clock.
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下丘脑后脑室旁核的催产素能细胞参与食物携带时钟。
DOI：
10.1038/s41598-021-99266-0
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发表时间：
2021-10-07
影响因子：
4.6
通讯作者：
Melo AI
中科院分区：
文献类型：
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作者：
Caba M;Meza E;Escobar C;Jiménez A;Caba-Flores MD;Moreno-Cortés ML;Melo AI
食物预期活动背后的机制仍然知之甚少。本文探讨了催产素(OT)和c-Fos蛋白在下丘脑室旁核视上核(SON)、内侧核(PVNm)和后核(PVNp)中的作用。将成年大鼠分为四组：程序限制喂食组(RF)、随意喂食组(AL)、限制喂食后禁食(RF-F)，以探讨振荡持续的可能性，或随意禁食(AL-F)。在SON和PVNm中，OT细胞在摄食后呈c-Fos阳性；相反，PVNp中的OT细胞在期待获得食物时表现出c-Fos的激活，这种情况在RF-F受试者中持续存在。我们的结论是，SON和PVNm的OT和非OT细胞可能是食物摄取提供的摄取信号的受体，而PVNp的那些含有投射到外周器官的运动自主前细胞的那些细胞可能参与了准备食物呈现的激素和代谢的预期变化，因此，可能是中枢和外周振荡器联系的一部分。此外，由于它们的持续激活，它们可能参与了导致食物夹带的时钟机制的神经网络。
The mechanisms underlying food anticipatory activity are still poorly understood. Here we explored the role of oxytocin (OT) and the protein c-Fos in the supraoptic nucleus (SON), medial (PVNm) and posterior (PVNp) regions of the paraventricular hypothalamic nucleus. Adult rats were assigned to one of four groups: scheduled restricted feeding (RF), ad libitum (AL), fasting after restricted feeding (RF-F), to explore the possible persistence of oscillations, or ad libitum fasted (AL-F). In the SON and in the PVNm, OT cells were c-Fos positive after food intake; in contrast, OT cells in the PVNp showed c-Fos activation in anticipation to food access, which persisted in RF-F subjects. We conclude that OT and non-OT cells of the SON and PVNm may play a role as recipients of the entraining signal provided by food intake, whereas those of the PVNp which contain motor preautonomic cells that project to peripheral organs, may be involved in the hormonal and metabolic anticipatory changes in preparation for food presentation and thus, may be part of a link between central and peripheral oscillators. In addition, due to their persistent activation they may participate in the neuronal network for the clock mechanism that leads to food entrainment.
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影响因子：
29
作者：
Johnstone, Louise E.;Fong, Tung M.;Leng, Gareth
通讯作者：
Leng, Gareth
影响因子：
3
作者：
ARLETTI, R;BENELLI, A;BERTOLINI, A
通讯作者：
BERTOLINI, A
影响因子：
5.3
作者：
Abe, M;Herzog, ED;Block, GD
通讯作者：
Block, GD
DOI：
10.1152/ajpregu.2000.279.6.r2048
发表时间：
2000-12-01
影响因子：
2.8
作者：
Díaz-Muñoz, M;Vázquez-Martínez, O;Escobar, C
通讯作者：
Escobar, C
刺激性室室核向AGRP神经元电路，驱动饥饿。
影响因子：
64.8
作者：
通讯作者：
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