Effects of Chinese herbal medicine on plasma glucose, protein and energy metabolism in sheep.
Effects of Chinese herbal medicine on plasma glucose, protein and energy metabolism in sheep.
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DOI：
10.1186/2049-1891-4-51
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发表时间：
2013-12-18
影响因子：
7
通讯作者：
Sano H
中科院分区：
文献类型：
--
作者：
Liang X;Yamazaki K;Kamruzzaman M;Bi X;Panthee A;Sano H
由于药物残留对人类健康的隐患，动物饲料中抗生素的使用正面临着负反馈。在过去的二十年里，传统的中草药已经被用来取代抗生素，并在畜牧业生产中发挥着越来越重要的作用。本研究旨在探讨中草药补料对绵羊血糖、蛋白质和能量代谢动力学的影响。并对其瘤胃发酵特性进行了测定。采用交叉设计，对4只绵羊分别饲喂混合干草日粮(MH日粮)或MH日粮加2%中草药(黄芪、当归、苍术的混合物；CHM日粮)，为期35天。采用[U-13C]葡萄糖同位素稀释法测定血浆葡萄糖周转率。用[1-13C]亮氨酸稀释法和开路量热法测定血浆亮氨酸转化率和亮氨酸氧化速率、全身蛋白质合成(WBPS)和代谢产热。中草药组绵羊增重显著高于高氢组(P = 0.03)。中草药组瘤胃pH低于高脂组(P = 0.02)，瘤胃总挥发性脂肪酸浓度高于高脂组(P = 0.05)，乙酸组高于高脂组(P = 0.04)。不同饮食之间血糖和亮氨酸的周转率没有差异。中草药日粮的亮氨酸氧化速率(PWBP0.06)高于高脂日粮(P<0.05)，但不同日粮之间的 = 差异不显著。中草药日粮的代谢产热倾向于大于中草药日粮(P< = >0.05)。饲喂中草药日粮的绵羊增重较高，对瘤胃发酵和能量代谢有积极影响，且不产生任何不良反应。因此，中草药混合物可作为绵羊潜在的饲料添加剂。
The use of antibiotics in animal diets is facing negative feedback due to the hidden danger of drug residues to human health. Traditional Chinese herbal medicine has been used to replace antibiotics in the past two decades and played an increasingly important role in livestock production. The present study was carried out to assess the feeding effects of a traditional nourishing Chinese herbal medicine mixture on kinetics of plasma glucose, protein and energy metabolism in sheep. Ruminal fermentation characteristics were also determined. Four sheep were fed on either mixed hay (MH-diet) or MH-diet supplemented with 2% of Chinese herbal medicine (mixture of Astragalus root, Angelica root and Atractylodes rhizome; CHM-diet) over two 35-day periods using a crossover design. The turnover rate of plasma glucose was measured with an isotope dilution method using [U-13C]glucose. The rates of plasma leucine turnover and leucine oxidation, whole body protein synthesis (WBPS) and metabolic heat production were measured using the [1-13C]leucine dilution and open circuit calorimetry. Body weight gain of sheep was higher (P = 0.03) for CHM-diet than for MH-diet. Rumen pH was lower (P = 0.02), concentration of rumen total volatile fatty acid tended to be higher (P = 0.05) and acetate was higher (P = 0.04) for CHM-diet than for MH-diet. Turnover rates of plasma glucose and leucine did not differ between diets. Oxidation rate of leucine tended to be higher (P = 0.06) for CHM-diet than for MH-diet, but the WBPS did not differ between diets. Metabolic heat production tended to be greater (P = 0.05) for CHM-diet than for MH-diet. The sheep fed on CHM-diet had a higher body weight gain and showed positive impacts on rumen fermentation and energy metabolism without resulting in any adverse response. Therefore, these results suggested that the Chinese herbal medicine mixture should be considered as a potential feed additive for sheep.
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影响因子：
3.3
作者：
FREEMAN, AS;GALYEAN, ML;CATON, JS
通讯作者：
CATON, JS
影响因子：
3.2
作者：
Chaves, A. V.;Stanford, K.;Benchaar, C.
通讯作者：
Benchaar, C.
影响因子：
3.2
作者：
Castillejos, L.;Calsamiglia, S.;Losa, R.
通讯作者：
Losa, R.
DOI：
10.1002/bms.1200080406
发表时间：
1981-01-01
期刊：
BIOMEDICAL MASS SPECTROMETRY
影响因子：
--
作者：
ROCCHICCIOLI, F;LEROUX, JP;CARTIER, P
通讯作者：
CARTIER, P
影响因子：
1.8
作者：
Lien, T. F.;Homg, Y. M.;Wu, C. P.
通讯作者：
Wu, C. P.