Structural and functional network mechanisms of rescuing cognitive control in aging.
Structural and functional network mechanisms of rescuing cognitive control in aging.
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DOI：
10.1016/j.neuroimage.2022.119547
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发表时间：
2022-11-15
期刊：
影响因子：
5.7
通讯作者：
Zanto, Theodore P.
中科院分区：
文献类型：
--
作者：
Jones, Kevin T.;Johnson, Elizabeth L.;Gazzaley, Adam;Zanto, Theodore P.
与年龄相关的认知控制能力下降威胁着个人的独立性，而认知控制能力是大多数日常任务的关键能力。我们之前在老年人和年轻人中表明，经颅交流电刺激（tACS）可以改善认知控制，在远离刺激部位的神经区域和刺激范围之外的频率中观察到效果。在这里，我们评估超出刺激部位的神经活动的网络水平变化，并评估促进这些影响的解剖通路。我们研究了当老年人连续三天进行认知控制视频游戏干预时，使用前额叶 (F3-F4) theta (6 Hz) 或控制 (1 Hz) tACS 来挽救衰老认知控制的潜力。通过脑电图测量额-后锁相值 (PLV) 相对于无 tACS 基线的每日变化来评估功能连接。使用基线时收集的 MRI 扩散纤维束成像数据来测量结构连接性。 Theta tACS 改善了多任务处理性能，个人收益反映了每日 PLV 变化的分离，其中 theta tACS 增强了 PLV，而对照 tACS 降低了 PLV。 θ tACS 组中增强的 α-β PLV 与下纵束和胼胝体完整性呈正相关，并进一步解释了多任务处理的增益。这些结果表明，theta tACS 可以通过加强功能连接（特别是在较高频段）来改善衰老过程中的认知控制。然而，功能连接增益的程度受到结构白质束完整性的限制。鉴于高龄与白质完整性下降相关，结果表明 tACS 作为治疗方法最好在高龄之前进行。
Age-related declines in cognitive control, an ability critical in most daily tasks, threaten individual independence. We previously showed in both older and younger adults that transcranial alternating current stimulation (tACS) can improve cognitive control, with effects observed across neural regions distant from the stimulated site and frequencies outside the stimulated range. Here, we assess network-level changes in neural activity that extend beyond the stimulated site and evaluate anatomical pathways that subserve these effects. We investigated the potential to rescue cognitive control in aging using prefrontal (F3-F4) theta (6 Hz) or control (1 Hz) tACS while older adults engaged in a cognitive control video game intervention on three consecutive days. Functional connectivity was assessed with EEG by measuring daily changes in frontal-posterior phase-locking values (PLV) from the tACS-free baseline. Structural connectivity was measured using MRI diffusion tractography data collected at baseline. Theta tACS improved multitasking performance, and individual gains reflected a dissociation in daily PLV changes, where theta tACS strengthened PLV and control tACS reduced PLV. Strengthened alpha-beta PLV in the theta tACS group correlated positively with inferior longitudinal fasciculus and corpus callosum body integrity, and further explained multitasking gains. These results demonstrate that theta tACS can improve cognitive control in aging by strengthening functional connectivity, particularly in higher frequency bands. However, the extent of functional connectivity gains is limited by the integrity of structural white matter tracts. Given that advanced age is associated with decreased white matter integrity, results suggest that the deployment of tACS as a therapeutic is best prior to advanced age.
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影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
DOI：
10.1093/cercor/bhaa365
发表时间：
2021-03-31
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Changeux JP;Goulas A;Hilgetag CC
通讯作者：
Hilgetag CC
影响因子：
3.7
作者：
Hinault, T.;Kraut, M.;Courtney, S. M.
通讯作者：
Courtney, S. M.
影响因子：
3.7
作者：
Davis, Simon W.;Dennis, Nancy A.;Cabeza, Roberto
通讯作者：
Cabeza, Roberto
影响因子：
7.7
作者：
Hsu, Wan-Yu;Zanto, Theodore P.;Gazzaley, Adam
通讯作者：
Gazzaley, Adam