Obesity as a premature aging phenotype - implications for sarcopenic obesity.
Obesity as a premature aging phenotype - implications for sarcopenic obesity.
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肥胖作为一种过早衰老的表型——对肌肉减少性肥胖的影响。
DOI：
10.1007/s11357-022-00567-7
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发表时间：
2022-06
期刊：
影响因子：
5.6
通讯作者：
Butcher, Joshua T.
中科院分区：
文献类型：
--
作者：
Nunan, Emily;Wright, Carson L.;Semola, Oluwayemisi A.;Subramanian, Madhan;Balasubramanian, Priya;Lovern, Pamela C.;Fancher, Ibra S.;Butcher, Joshua T.
肥胖和老龄化在整个社会中的流行率都出现了戏剧性的增长。这篇综述试图强调肥胖的常见病理以及潜在的危险因素，这些因素与老年人观察到的有显著的相似之处。这些包括骨骼肌功能障碍(数量和质量的丧失)，肥胖症的显著增加，自主神经功能障碍的全身性改变，一氧化氮生物利用度的降低，氧化应激和炎症的增加，葡萄糖稳态的失调，以及线粒体功能障碍。这篇综述是由上述指数组织的，并简明扼要地突出了在人类和动物模型中老年和肥胖表型之间的相似性的文献。由于衰老是不可避免的，肥胖率在不久的将来不太可能大幅下降，这两种表型最终将合并为一种多维综合征(一种病理学称为骨质疏松症)。伴随肥胖的早熟衰老指标在进入衰老后是相加的还是协同的，目前还没有很好的定义，但这篇综述的目的是阐明双衰老表型在骨质源性肥胖中的潜在后果。临床上，可改变的危险因素可以专门针对肥胖症，以延长老年和骨脂性肥胖症人群的健康寿命。
Obesity and aging have both seen dramatic increases in prevalence throughout society. This review seeks to highlight common pathologies that present with obesity, along with the underlying risk factors, that have remarkable similarity to what is observed in the aged. These include skeletal muscle dysfunction (loss of quantity and quality), significant increases in adiposity, systemic alterations to autonomic dysfunction, reduction in nitric oxide bioavailability, increases in oxidant stress and inflammation, dysregulation of glucose homeostasis, and mitochondrial dysfunction. This review is organized by the aforementioned indices and succinctly highlights literature that demonstrates similarities between the aged and obese phenotypes in both human and animal models. As aging is an inevitability and obesity prevalence is unlikely to significantly decrease in the near future, these two phenotypes will ultimately combine as a multidimensional syndrome (a pathology termed sarcopenic obesity). Whether the pre-mature aging indices accompanying obesity are additive or synergistic upon entering aging is not yet well defined, but the goal of this review is to illustrate the potential consequences of a double aged phenotype in sarcopenic obesity. Clinically, the modifiable risk factors could be targeted specifically in obesity to allow for increased health span in the aged and sarcopenic obese populations.
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影响因子：
11.1
作者：
Carlson, Morgan E.;Suetta, Charlotte;Conboy, Michael J.;Aagaard, Per;Mackey, Abigail;Kjaer, Michael;Conboy, Irina
通讯作者：
Conboy, Irina
影响因子：
2.7
作者：
Day, Kenneth;Shefer, Gabi;Yablonka-Reuveni, Zipora
通讯作者：
Yablonka-Reuveni, Zipora
影响因子：
9.8
作者：
COLMAN, E;KATZEL, LI;GOLDBERG, AP
通讯作者：
GOLDBERG, AP
影响因子：
5.2
作者：
Bretherton, Beatrice;Atkinson, Lucy;Deuchars, Jim
通讯作者：
Deuchars, Jim
影响因子：
3.2
作者：
Derby, Carol A.;Zilber, Sophia;McKinlay, John B.
通讯作者：
McKinlay, John B.