Network Mechanisms of Clinical Response to Transcranial Magnetic Stimulation in Posttraumatic Stress Disorder and Major Depressive Disorder.
Network Mechanisms of Clinical Response to Transcranial Magnetic Stimulation in Posttraumatic Stress Disorder and Major Depressive Disorder.
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创伤后应激障碍和重性抑郁障碍对经颅磁刺激临床反应的网络机制。
DOI：
10.1016/j.biopsych.2017.07.021
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发表时间：
2018-02-01
影响因子：
10.6
通讯作者：
Carpenter LL
中科院分区：
文献类型：
--
作者：
Philip NS;Barredo J;van 't Wout-Frank M;Tyrka AR;Price LH;Carpenter LL
Repetitive transcranial magnetic stimulation (TMS) therapy can modulate pathological neural network functional connectivity in major depressive disorder (MDD). Posttraumatic stress disorder (PTSD) is often comorbid with MDD, and symptoms of both disorders can be alleviated with TMS therapy. This is the first study to evaluate TMS-associated changes in connectivity in patients with comorbid PTSD and MDD. Resting state functional connectivity magnetic resonance imaging was acquired before and after TMS therapy in 33 adult outpatients in a prospective open trial. 5Hz TMS was delivered, in up to 40 daily sessions, to left dorsolateral prefrontal cortex (DLPFC). Analyses used a priori seeds relevant to TMS, PTSD or MDD (subgenual anterior cingulate cortex (sgACC), DLPFC, hippocampus, and basolateral amygdala) to identify imaging predictors of response and to evaluate clinically relevant changes in connectivity after TMS, followed by leave-one-out cross validation. Imaging results were explored using data-driven multivoxel pattern activation (MVPA). More negative pretreatment connectivity between sgACC and default mode network (DMN) predicted clinical improvement, as did more positive amygdala-to-ventromedial prefrontal cortex connectivity. After TMS, symptom reduction was associated with reduced connectivity between sgACC and DMN, DLPFC, and insula, and reduced connectivity between hippocampus and salience network (SN). MVPA confirmed seed-based predictors and correlates of treatment outcomes. These results highlight the central role of the sgACC, DMN and SN as predictors of TMS response, and suggest their involvement in mechanisms of action. Furthermore, this work indicates there may be network-based biomarkers of clinical response relevant to these commonly comorbid disorders. (5Hz Repetitive Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder Comorbid With Major Depressive Disorder; ClinicalTrials.gov; )
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影响因子：
11.3
作者：
Godard, Julie;Baruch, Philippe;Lafleur, Martin F.
通讯作者：
Lafleur, Martin F.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1073/pnas.1405003111
发表时间：
2014-10-14
影响因子：
11.1
作者：
Fox, Michael D.;Buckner, Randy L.;Pascual-Leone, Alvaro
通讯作者：
Pascual-Leone, Alvaro
影响因子：
11.3
作者：
Cisler JM;Scott Steele J;Smitherman S;Lenow JK;Kilts CD
通讯作者：
Kilts CD
影响因子：
3.3
作者：
Drevets, Wayne C.;Savitz, Jonathan
通讯作者：
Savitz, Jonathan