Multiwalled nanotubes formed by catanionic mixtures of drug amphiphiles.
Multiwalled nanotubes formed by catanionic mixtures of drug amphiphiles.
复制标题
DOI：
10.1021/nn505688b
复制
发表时间：
2014-12-23
期刊：
影响因子：
17.1
通讯作者：
Cui, Honggang
中科院分区：
文献类型：
--
作者：
Lin, Yi-An;Cheetham, Andrew G.;Zhang, Pengcheng;Ou, Yu-Chuan;Li, Yuguo;Liu, Guanshu;Hermida-Merino, Daniel;Hamley, Ian W.;Cui, Honggang
混合带相反电荷的两亲分子（阳离子混合）提供了一种有吸引力的策略，可以产生不同于单个分子形成的形态。我们在这里报道了使用抗肿瘤药物两亲分子的阳离子混合来构建含有固定和高载药量的多壁纳米管。我们发现，分子混合比、溶剂组成、药物总浓度以及所研究的两亲分子的分子设计都是影响管状形态的重要实验参数。我们相信这些结果证明了抗癌药物具有显著的潜力，可以提供自组装成离散的纳米结构，并且也为碳负离子混合物形成纳米管的机制提供了重要的见解。我们的初步动物研究表明，在肿瘤内注射CPT纳米管后，CPT纳米管在肿瘤部位的滞留时间显着延长。
Mixing of oppositely charged amphiphilic molecules (catanionic mixing) offers an attractive strategy to produce morphologies different from those formed by individual molecules. We report here on the use of catanionic mixing of anticancer drug amphiphiles to construct multiwalled nanotubes containing a fixed and high drug loading. We found that the molecular mixing ratio, the solvent composition, the overall drug concentrations, as well as the molecular design of the studied amphiphiles are all important experimental parameters contributing to the tubular morphology. We believe these results demonstrate the remarkable potential that anticancer drugs could offer to self-assemble into discrete nanostructures and also provide important insight into the formation mechanism of nanotubes by catanionic mixtures. Our preliminary animal studies reveal that the CPT nanotubes show significantly prolonged retention time in the tumor site after intratumoral injection.
登录
查看更多内容
DOI：
10.1039/c3cc49453e
发表时间：
2014-06-07
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
Cheetham AG;Ou YC;Zhang P;Cui H
通讯作者：
Cui H
影响因子：
64.8
作者：
GHADIRI, MR;GRANJA, JR;KHAZANOVICH, N
通讯作者：
KHAZANOVICH, N
影响因子：
15
作者：
Cheetham, Andrew G.;Zhang, Pengcheng;Lin, Yi-an;Lock, Lye Lin;Cui, Honggang
通讯作者：
Cui, Honggang
影响因子：
3.9
作者：
Hamley, I. W.;Dehsorkhi, A.;Castelletto, V.
通讯作者：
Castelletto, V.
影响因子：
38.3
作者：
Adler-Abramovich, Lihi;Aronov, Daniel;Gazit, Ehud
通讯作者：
Gazit, Ehud