Improved memory function 12 weeks after bariatric surgery.
Improved memory function 12 weeks after bariatric surgery.
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DOI：
10.1016/j.soard.2010.09.015
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发表时间：
2011-07
影响因子：
3.1
通讯作者：
Mitchell, James E.
中科院分区：
文献类型：
--
作者：
Gunstad, John;Strain, Gladys;Devlin, Michael J.;Wing, Rena;Cohen, Ronald A.;Paul, Robert H.;Crosby, Ross D.;Mitchell, James E.
越来越多的证据表明肥胖与神经认知结果不佳有关。减肥手术是治疗病态肥胖的有效干预措施，可以改善许多与认知功能障碍相关的合并症。减肥手术对认知的影响尚不清楚。前瞻性研究共有 150 名受试者（109 名参加减肥手术纵向评估 (LABS) 项目的减肥手术患者和 41 名未接受手术的肥胖对照者）在基线和 12 周随访时完成了认知评估。还收集了人口统计、医疗和社会心理信息，以阐明可能的变化机制。许多减肥手术患者在基线认知测试中表现出受损的表现（范围为 4.6%–23.9%）。然而，在 12 周的随访中，手术患者在两项或多项认知测试中表现出下降的可能性并不比肥胖对照组高 [12.84% vs. 23.26%； χ2 (1) = 2.51，p = .11]。使用重复测量多元方差分析进行的组比较显示，手术患者在 12 周随访时记忆表现有所改善 [λ = .86，F(4, 147) = 5.88，p<.001]，而肥胖对照实际上有所下降。回归分析显示，没有高血压的手术患者在 12 周时的短延迟回忆能力比那些患有高血压的患者更好 [β = 0.31，p = .005]，尽管其他人口统计和医学变量在很大程度上与测试表现无关。目前的结果表明，认知障碍在减肥手术患者中很常见，尽管这些缺陷可能至少部分可逆。未来的研究需要阐明潜在的机制，特别是采用神经影像学和血液标记物的纵向研究。
There is growing evidence that obesity is associated with poor neurocognitive outcome. Bariatric surgery is an effective intervention for morbid obesity and improves many comorbid medical conditions that are associated with cognitive dysfunction. The effects of bariatric surgery on cognition are unknown. Prospective study total of 150 individuals (109 bariatric surgery patients enrolled in the Longitudinal Assessment of Bariatric Surgery (LABS) project and 41 obese controls that did not undergo surgery) completed cognitive evaluation at baseline and 12 week follow-up. Demographic, medical, and psychosocial information was also collected to elucidate possible mechanisms of change. Many bariatric surgery patients exhibited impaired performance on cognitive testing at baseline (range from 4.6%–23.9%). However, surgery patients were no more likely to exhibit decline on two or more cognitive tests at 12-week follow-up than obese controls [12.84% vs. 23.26%; χ2 (1) = 2.51, p = .11]. Group comparisons using repeated measures MANOVA showed surgery patients had improved memory performance at 12 week follow-up [λ = .86, F(4, 147) = 5.88, p<.001], whereas obese controls actually declined. Regression analyses showed surgery patients without hypertension had better short delay recall at 12 weeks than those that did [β = 0.31, p = .005], though other demographic and medical variables were largely unrelated to test performance. The current results suggest that cognitive impairment is common in bariatric surgery patients, though these deficits may be at least partly reversible. Future studies are needed to clarify underlying mechanisms, particularly longitudinal studies employing neuroimaging and blood markers.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
DOI：
10.1111/j.1532-5415.1998.tb04542.x
发表时间：
1998-10-01
影响因子：
6.3
作者：
Dijkstra, JB;Van Boxtel, MPJ;Jolles, J
通讯作者：
Jolles, J
影响因子：
4.5
作者：
Chui, Michael Herman;Greenwood, Carol E.
通讯作者：
Greenwood, Carol E.
影响因子：
7.2
作者：
Ettenhofer, Mark L.;Hinkin, Charles H.;Foley, Jessica
通讯作者：
Foley, Jessica
影响因子：
3.1
作者：
Belle, Steven H.;Berk, Paul D.;Yanovski, Susan Z.
通讯作者：
Yanovski, Susan Z.