Analysis of factors that influence the occurrence of otitis media with effusion in pediatric patients with adenoid hypertrophy.
Analysis of factors that influence the occurrence of otitis media with effusion in pediatric patients with adenoid hypertrophy.
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腺样体肥大患儿发生渗出性中耳炎的影响因素分析
DOI：
10.3389/fped.2023.1098067
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发表时间：
2023
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
目的腺样体肥大（AH）和渗出性中耳炎（OME）是儿科常见的耳鼻喉科疾病，常并发。本研究的目的是综合分析影响AH患儿OME发生的因素。方法纳入2018年3月至2022年2月期间在中国北京清华长庚医院住院治疗的12岁以下AH患者。根据是否存在OME将患者分为AH组和AH + OME组。作者收集以下临床资料进行单变量分析：性别；年龄;体重指数（BMI）；合并鼻塞/鼻漏、复发性扁桃体炎或过敏性鼻炎（AR）；腺样体和扁桃体分级；扁桃体肥大;食物/药物过敏;腺样体切除术史与先天性疾病；母乳喂养状况;早产;接触环境烟草烟雾；腺扁桃体切除术、中耳炎和AR家族史；部分患者多导睡眠图主要资料及口咽条件致病菌培养资料。单因素分析作为logistic回归分析的基础。结果共纳入511例儿童，其中男孩329例，女孩182例，平均年龄5.37±2.10岁。其中AH组407例（79.6%），AH + OME组104例（20.4%）。单变量分析显示，两组在年龄、BMI、腺样体分级、AR、母乳喂养状况和ETS暴露方面存在统计学差异。多因素逐步logistic回归分析显示，年龄、腺样体分级、AR、母乳喂养状况和ETS影响AH患儿OME的发生。OME的风险随着年龄的增长而降低。高腺样体分级、ETS暴露和合并症AR是AH患儿发生OME的危险因素，但母乳喂养是一个保护因素。口咽部条件病原菌培养数据的最终分析结果显示，AH中肺炎链球菌阳性与OME相关。结论AH合并OME的发病机制复杂。年幼、高腺样体分级、ETS暴露、非母乳喂养状态、合并症AR以及口咽部存在肺炎链球菌是AH患儿发生OME的危险因素。
Objective Adenoid hypertrophy (AH) and otitis media with effusion (OME) are common pediatric otolaryngological diseases and often occur concurrently. The purpose of this study was to comprehensively analyze the factors that influence the occurrence of OME pediatric patients with AH. Methods Patients younger than 12 years with AH, who were hospitalized for treatment at Beijing Tsinghua Changgung Hospital in Beijing, China, between March 2018 and February 2022 were enrolled. The patients were divided into an AH group and an AH + OME group based on the presence of OME. The authors collected the following clinical data for univariable analysis: sex; age; body mass index (BMI); comorbid nasal congestion/rhinorrhea, recurrent tonsillitis, or allergic rhinitis (AR); adenoid and tonsil grade; tonsillar hypertrophy; food/drug allergy; history of adenoidectomy and congenital diseases; breastfeeding status; preterm birth; exposure to environmental tobacco smoke (ETS); family history of adenotonsillectomy, otitis media, and AR; main data of polysomnography and oropharyngeal conditional pathogen culture data of some patients. Univariate analysis was performed as a basis for logistic regression analysis. Results A total of 511 children (329 boys and 182 girls) were included, their mean age was 5.37 ± 2.10 years. Of them, 407 (79.6%) were in the AH group and 104 (20.4%) in the AH + OME group. Univariate analysis revealed statistically significant differences in age, BMI, adenoid grade, AR, breastfeeding status, and ETS exposure between the two groups. Multivariate stepwise logistic regression analysis showed that age, adenoid grade, AR, breastfeeding status, and ETS influenced the occurrence of OME in pediatric patients with AH. The risk of OME decreased with increasing age. High adenoid grade, ETS exposure, and comorbid AR were risk factors for OME in pediatric patients with AH, but breastfeeding was a protective factor. The final analytical results of the oropharyngeal conditional pathogen culture data showed that Streptococcus pneumoniae positivity was associated with OME in AH. Conclusion The pathogenesis of AH with OME is complex. Young age, high adenoid grade, ETS exposure, non-breastfed status, comorbid AR, and the presence of S. pneumoniae in the oropharynx are risk factors for OME in pediatric patients with AH.
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影响因子：
0.6
作者：
Galić MZ;Klančnik M
通讯作者：
Klančnik M
影响因子：
2.6
作者：
Chan, Chun Ling;Wabnitz, David;Psaltis, Alkis James
通讯作者：
Psaltis, Alkis James
DOI：
10.1016/j.ijporl.2015.02.017
发表时间：
2015-05-01
影响因子：
1.5
作者：
Evcimik, Muhammed Fatih;Dogru, Mahmut;Nepesov, Merve Iseri
通讯作者：
Nepesov, Merve Iseri
影响因子：
5.6
作者：
Jung SY;Kim D;Park DC;Lee EH;Choi YS;Ryu J;Kim SH;Yeo SG
通讯作者：
Yeo SG
影响因子：
1.3
作者：
Abdel Tawab, Hazem M.;Tabook, Salim M. Sloma
通讯作者：
Tabook, Salim M. Sloma