Immunoglobulins and Transcription Factors in Otitis Media.
Immunoglobulins and Transcription Factors in Otitis Media.
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DOI：
10.3390/ijms22063201
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发表时间：
2021-03-21
影响因子：
5.6
通讯作者：
Yeo SG
中科院分区：
文献类型：
--
作者：
Jung SY;Kim D;Park DC;Lee EH;Choi YS;Ryu J;Kim SH;Yeo SG
中耳炎（OM）的原因涉及细菌和病毒感染、耳咽管和鼻咽的解剖生理异常、过敏性鼻炎、集体托儿中心、二手烟、肥胖、免疫系统的不成熟和缺陷、配方奶粉喂养、性别、种族和年龄。OM伴随着细菌、病毒、炎症细胞、免疫细胞和上皮细胞之间复杂多样的相互作用。本研究总结了在所有类型的中耳炎，包括急性中耳炎，分泌性中耳炎，慢性中耳炎伴或不伴中耳炎的免疫反应的抗体，以及诱导这些抗体产生的转录因子。B细胞的类型和分布; B细胞的功能，特别是在耳鼻喉科;中耳炎患者的抗体形成;抗体和相关转录因子的描述。B细胞在宿主防御中具有重要功能，包括抗原识别、抗原呈递、抗体产生和免疫调节。耳、鼻、喉（尤其是中耳炎患者）中B细胞的表型显示为CD 5低、CD 23高、CD 43低、B220高、sIgM低、sIgD高、Mac-1低、CD 80（B7.1）低、CD 86（B7.2）低和Syndecam-1低。在由B细胞产生的五种主要类型的免疫球蛋白中，三种（IgG、伊加和IgM）主要涉及中耳炎。分泌性中耳炎（OME）患者血清IgG、伊加和IgM浓度低于无中耳炎的受试者。此外，中耳腔中的IgG、伊加和IgM浓度在中耳炎患者的免疫应答期间增加。B细胞白血病/淋巴瘤-6（Bcl-6）和配对盒基因5（Pax-5）抑制抗体产生，而B淋巴细胞成熟程序诱导物1（Blimp-1）和X盒结合蛋白1（XBP-1）促进中耳炎患者免疫应答期间的抗体产生。
The causes of otitis media (OM) involve bacterial and viral infection, anatomo-physiological abnormalities of the Eustachian canal and nasopharynx, allergic rhinitis, group childcare centers, second-hand smoking, obesity, immaturity and defects of the immune system, formula feeding, sex, race, and age. OM is accompanied by complex and diverse interactions among bacteria, viruses, inflammatory cells, immune cells, and epithelial cells. The present study summarizes the antibodies that contribute to immune reactions in all types of otitis media, including acute otitis media, otitis media with effusion, and chronic otitis media with or without cholesteatoma, as well as the transcription factors that induce the production of these antibodies. The types and distribution of B cells; the functions of B cells, especially in otorhinolaryngology; antibody formation in patients with otitis media; and antibodies and related transcription factors are described. B cells have important functions in host defenses, including antigen recognition, antigen presentation, antibody production, and immunomodulation. The phenotypes of B cells in the ear, nose, and throat, especially in patients with otitis media, were shown to be CD5low, CD23high, CD43low, B220high, sIgMlow, sIgDhigh, Mac-1low, CD80(B7.1)low, CD86(B7.2)low, and Syndecam-1low. Of the five major classes of immunoglobulins produced by B cells, three (IgG, IgA, and IgM) are mainly involved in otitis media. Serum concentrations of IgG, IgA, and IgM are lower in patients with OM with effusion (OME) than in subjects without otitis media. Moreover, IgG, IgA, and IgM concentrations in the middle ear cavity are increased during immune responses in patients with otitis media. B cell leukemia/lymphoma-6 (Bcl-6) and paired box gene 5 (Pax-5) suppress antibody production, whereas B lymphocyte inducer of maturation program 1 (Blimp-1) and X-box binding protein 1 (XBP-1) promote antibody production during immune responses in patients with otitis media.
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影响因子：
4.4
作者：
Kusam, Saritha;Dent, Alexander
通讯作者：
Dent, Alexander
影响因子：
2.1
作者：
Drake-Lee, AB;Hughes, RG;Dunn, C
通讯作者：
Dunn, C
影响因子：
3.1
作者：
FADEN, H;HONG, J;MURPHY, T
通讯作者：
MURPHY, T
影响因子：
--
作者：
Kaur, Ravinder;Kim, Thomas;Pichichero, Michael E.
通讯作者：
Pichichero, Michael E.
DOI：
10.1159/000163035
发表时间：
2008-01-01
期刊：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES
影响因子：
--
作者：
Lasisi, Akeem O.;Arinola, Olatubosun G.;Bakare, Rasheed A.
通讯作者：
Bakare, Rasheed A.