Association of serum adiponectin, leptin, and resistin concentrations with the severity of liver dysfunction and the disease complications in alcoholic liver disease.
Association of serum adiponectin, leptin, and resistin concentrations with the severity of liver dysfunction and the disease complications in alcoholic liver disease.
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DOI：
10.1155/2013/148526
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发表时间：
2013
影响因子：
4.6
通讯作者：
Szczerbinski M
中科院分区：
文献类型：
--
作者：
Kasztelan-Szczerbinska B;Surdacka A;Slomka M;Rolinski J;Celinski K;Smolen A;Szczerbinski M
背景和目标。越来越多的证据表明白色脂肪组织在酒精性肝病(ALD)的发病机制中起重要作用。我们研究了慢性酒精滥用和不同程度肝功能障碍患者的血清总脂联素(Acrp30)、瘦素和抵抗素浓度，以及ALD并发症。材料和方法前瞻性招募了147名连续住院的肌萎缩侧索硬化症患者。用免疫酶酶联免疫吸附试验检测血浆脂肪因子水平。应用多变量Logistic回归分析筛选晚期肝功能障碍和疾病并发症的独立预测因素。结果。ALD患者Acrp30和抵抗素水平显著高于对照组。与对照组相比，女性ALD患者的瘦素水平较低，但男性的瘦素水平没有显著差异。高血清Acrp30水平与晚期肝功能障碍以及ALD并发症(即腹水和肝性脑病)的发展独立相关。结论。血清瘦素浓度的性别差异可能会影响ALD的病程，女性与男性不同。血清Acrp30水平可作为ALD患者潜在的预后指标。
Background and aims. There is growing evidence that white adipose tissue is an important contributor in the pathogenesis of alcoholic liver disease (ALD). We investigated serum concentrations of total adiponectin (Acrp30), leptin, and resistin in patients with chronic alcohol abuse and different grades of liver dysfunction, as well as ALD complications. Materials and Methods. One hundred forty-seven consecutive inpatients with ALD were prospectively recruited. The evaluation of plasma adipokine levels was performed using immunoenzymatic ELISA tests. Multivariable logistic regression was applied in order to select independent predictors of advanced liver dysfunction and the disease complications. Results. Acrp30 and resistin levels were significantly higher in patients with ALD than in controls. Lower leptin levels in females with ALD compared to controls, but no significant differences in leptin concentrations in males, were found. High serum Acrp30 level revealed an independent association with advanced liver dysfunction, as well as the development of ALD complications, that is, ascites and hepatic encephalopathy. Conclusion. Gender-related differences in serum leptin concentrations may influence the ALD course, different in females compared with males. Serum Acrp30 level may serve as a potential prognostic indicator for patients with ALD.
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影响因子：
5.3
作者：
Beatty AL;Zhang MH;Ku IA;Na B;Schiller NB;Whooley MA
通讯作者：
Whooley MA
DOI：
10.4021/jocmr1159w
发表时间：
2013-06
期刊：
Journal of clinical medicine research
影响因子：
--
作者：
Aguiar-Nemer AS;Toffolo MC;da Silva CJ;Laranjeira R;Silva-Fonseca VA
通讯作者：
Silva-Fonseca VA
影响因子：
6.3
作者：
Durazzo, Marilena;Niro, Grazia;Floreani, Annarosa
通讯作者：
Floreani, Annarosa
影响因子：
19.6
作者：
Axelsson, J;Bergsten, A;Stenvinkel, P
通讯作者：
Stenvinkel, P
影响因子：
25.7
作者：
Greco, AV;Mingrone, G;Gasbarrini, G
通讯作者：
Gasbarrini, G