Imaging small vessel-associated white matter changes in aging.

Imaging small vessel-associated white matter changes in aging.
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DOI:
10.1016/j.neuroscience.2013.11.041
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发表时间:
2014-09-12
期刊:
影响因子:
3.3
通讯作者:
Salat, D. H.
Salat, D. H.
中科院分区:
医学3区
文献类型:
--
作者:
Salat, D. H.

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Alterations in cerebrovascular structure and function may underlie the most common age-associated cognitive, psychiatric, and neurological conditions presented by older adults. Although much remains to understand, existing research suggests several age-associated detrimental conditions may be mediated through sometimes subtle small vessel-induced damage to the cerebral white matter. Here we review a selected portion of the vast work that demonstrates links between changes in vascular and neural health as a function of advancing age, and how even changes in low-to-moderate risk individuals, potentially beginning early in the adult age-span, may have an important impact on functional status in late life.
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