Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging.
Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging.
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DOI：
10.1016/j.pscychresns.2008.11.006
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发表时间：
2009-05-15
影响因子：
2.3
通讯作者：
Stern, Yaakov
中科院分区：
文献类型：
--
作者：
Brickman, Adam M.;Zahra, Amir;Muraskin, Jordan;Steffener, Jason;Holland, Christopher M.;Habeck, Christian;Borogovac, Ajna;Ramos, Marco A.;Brown, Truman R.;Asllani, Iris;Stern, Yaakov
本初步研究的目的是检查脑血流量（CBF）的动脉自旋标记（ASL）的组织分类为白色高信号（WMH），正常出现的白色物质，和灰质。17名健康老年人接受了结构和ASL MRI。脑血流量来自三种组织类型：WMH，正常外观的白色物质和灰质。相对于正常出现的白色物质，WMH区域的脑血流量较低，而白色物质又低于灰质。个体间CBF持续较低的区域更有可能出现WMH。结果与一个新兴的文献相一致，该文献将区域灌注减少与发生WMH的风险联系起来。
The purpose of this preliminary study was to examine cerebral blood flow (CBF) as measured by arterial spin labeling (ASL) in tissue classified as white matter hyperintensities (WMH), normal appearing white matter, and grey matter. Seventeen healthy older adults received structural and ASL MRI. Cerebral blood flow was derived for three tissue types: WMH, normal appearing white matter, and grey matter. Cerebral blood flow was lower in WMH areas relative to normal appearing white matter, which in turn, was lower than grey matter. Regions with consistently lower CBF across individuals were more likely to appear as WMH. Results are consistent with an emerging literature linking diminished regional perfusion with the risk of developing WMH.
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影响因子：
8.3
作者：
Marstrand, JR;Garde, E;Larsson, HBW
通讯作者：
Larsson, HBW
影响因子：
9.9
作者：
Gurol, ME;Irizarry, MC;Greenberg, SM
通讯作者：
Greenberg, SM
影响因子：
8.3
作者：
Holland, Christopher M.;Smith, Eric E.;Greenberg, Steven M.
通讯作者：
Greenberg, Steven M.
影响因子：
19.7
作者：
ten Dam, V. Hester;van den Heuvel, Dominique M. J.;van Buchem, Mark A.
通讯作者：
van Buchem, Mark A.
影响因子：
--
作者：
Brickman, Adam M.;Honig, Lawrence S.;Scarmeas, Nikolaos;Tatarina, Oksana;Sanders, Linda;Albert, Marilyn S.;Brandt, Jason;Blacker, Deborah;Stern, Yaakov
通讯作者：
Stern, Yaakov