Qianliening capsule treats benign prostatic hyperplasia through regulating the expression of sex hormones, estrogen receptor and androgen receptor
Qianliening capsule treats benign prostatic hyperplasia through regulating the expression of sex hormones, estrogen receptor and androgen receptor
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前列宁胶囊通过调节性激素、雌激素受体、雄激素受体表达治疗良性前列腺增生
DOI：
10.5897/ajpp11.547
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发表时间：
2012-01
影响因子：
--
通讯作者：
Jun Peng
中科院分区：
文献类型：
--
作者：
Jianheng Zhou;Jiumao Lin;Xu Wei;Xiaoyong Zhong;Yuqing Zheng;Zhenfeng Hong;Jun Peng
本研究旨在评价前列宁胶囊（QLNC）对良性前列腺增生（BPH）大鼠血清激素、前列腺雌激素受体和雄激素受体表达水平的影响，并探讨其抗BPH活性的可能分子机制。生成雄性 Sprage-Dawley (SD) 大鼠 BPH 模型。 BPH大鼠口服不同浓度的QLNC。获得动物的血液和前列腺组织。评估前列腺重量（PW）和前列腺指数（PI）；镜下观察前列腺组织的组织病理学变化，血清睾酮和雌二醇水平，苏木精和伊红染色、HE染色、ELISA、RT-PCR、免疫组化分别检测前列腺组织中ER和AR的mRNA和蛋白表达。与模型组相比，所有 QLNC 治疗组的血清 PW 和 PI 均显着降低（p<0.05），而 QLNC 治疗组的 T/E2 显着升高（p<0.05 或 p<0.01）。 QLNC 治疗组前列腺组织的病理形态有所改善。 QLNC治疗组ER和AR的mRNA和蛋白表达显着下降。 QLNC对BPH大鼠有显着的治疗作用。改善性激素紊乱、调节ER、AR是QLNC治疗BPH的机制之一。
关键词：良性前列腺增生；前列宁胶囊；性激素；雌激素受体；雄激素受体。
The objective of the study to evaluate the effect of Qianliening capsule (QLNC) on the expression levels of serum hormones, prostatic estrogen receptor and androgen receptor in benign prostatic hyperplasia (BPH) rats, and investigate the possible molecular mechanisms mediating its anti-BPH activity. Male Sprage-Dawley (SD) rat BPH model was generated. BPH rats were orally treated with different concentrations of QLNC. Blood and the prostatic tissues of animals were obtained. The prostatic weight (PW) and prostatic index (PI) were evaluated; the histopathological changes of prostatic tissue, the levels of serum testosterone and estradiol, the mRNA and protein expression of ER and AR in prostatic tissue were examined by microscopy with hematoxylin and eosin staining HE staining, ELISA, RT-PCR, immunohistochemistry, respectively. Compared to the model group, the PW and PI in all QLNC-treated groups have significantly lower (p<0.05) serum than T/E2 in QLNC-treated groups which was elevated significantly (p<0.05 or p< 0.01). Pathomorphism of prostatic tissue in QLNC-treated groups improved. The mRNA and protein expression of ER and AR in QLNC-treated groups decreased significantly. QLNC has significant therapeutic effect on BPH rats. Improvement of sex hormones disorder and regulation of ER and AR are one of the mechanisms by which QLNC treats BPH.
Key words: Benign prostatic hyperplasia; Qianliening capsule; sex hormones; estrogen receptor; androgen receptor.
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影响因子：
2.4
作者：
Nickel, J. Curtis
通讯作者：
Nickel, J. Curtis
影响因子：
2.9
作者：
Ying Zhou;Xiangqian Xiao;Linfeng Chen;Rui Yang;Jian-dang Shi;Xiao-Ling Du;H. Klocker;I. Park;Chung Lee;Ju Zhang
通讯作者：
Ying Zhou;Xiangqian Xiao;Linfeng Chen;Rui Yang;Jian-dang Shi;Xiao-Ling Du;H. Klocker;I. Park;Chung Lee;Ju Zhang
影响因子：
4
作者：
Ho, Clement K. M.;Nanda, Jyoti;Habib, Fouad K.
通讯作者：
Habib, Fouad K.
DOI：
10.1152/ajpendo.2001.280.1.e120
发表时间：
2001
期刊：
American journal of physiology. Endocrinology and metabolism
影响因子：
--
作者：
F. Coppenolle;Christian Slomianny;Françoise Carpentier;X. Bourhis;Ahmed Ahidouch;D. Croix;Guillaume Legrand;E. Dewailly;Sarah Fournier;Henri Cousse;Dominique Authie;Jean-Pierre Raynaud;J. Beauvillain;Jean-Paul Dupouy;Natalia Prevarskaya
通讯作者：
F. Coppenolle;Christian Slomianny;Françoise Carpentier;X. Bourhis;Ahmed Ahidouch;D. Croix;Guillaume Legrand;E. Dewailly;Sarah Fournier;Henri Cousse;Dominique Authie;Jean-Pierre Raynaud;J. Beauvillain;Jean-Paul Dupouy;Natalia Prevarskaya
DOI：
--
发表时间：
2010
期刊：
Chinese Archives of Traditional Chinese Medicine
影响因子：
--
作者：
Hong Zhen-feng
通讯作者：
Hong Zhen-feng