Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa.
Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa.
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DOI：
10.1016/j.nicl.2013.12.002
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发表时间：
2014
影响因子：
4.2
通讯作者：
Tchanturia, Kate
中科院分区：
文献类型：
--
作者：
Fonville, Leon;Giampietro, Vincent;Surguladze, Simon;Williams, Steven;Tchanturia, Kate
神经性厌食症（AN）的行为文献表明心理社会功能受损，使用面部表情处理任务（FEPT）的研究报告了识别能力较差和识别情绪较慢。功能磁共振成像（fMRI）与FEPT一起使用，描绘中性，轻度快乐和快乐的面孔，以检查AN内隐情绪加工的神经相关性。参与者被要求指定面部的性别。获得抑郁、焦虑、强迫症状和进食障碍行为的水平，并进行主成分分析（PCA）以获得不相关的变量。功能磁共振成像分析显示，更大的血氧水平依赖（BOLD）的反应，在AN在右侧梭状回所有的面部表情。这种反应随着面部表情的幸福程度呈线性增长，并且在那些没有服用药物的人中表现得更强。PCA分析显示单一成分，表明一般临床症状水平较高。神经影像学研究结果表明，AN的内隐情绪处理的改变发生在社会信号的早期感知处理过程中，并说明FEPT的参与度更高。使用主成分分析缺乏单独的组成部分，这表明所使用的调查表可能不适合作为预测措施。AN中右侧梭状回对所有面部表情的BOLD反应更大。BOLD反应表现出与表达的幸福感呈线性增加。BOLD反应在那些没有服用精神药物的人中更强。这些变化发生在社会信号的早期知觉处理过程中。
The behavioural literature in anorexia nervosa (AN) has suggested impairments in psychosocial functioning and studies using facial expression processing tasks (FEPT) have reported poorer recognition and slower identification of emotions. Functional magnetic resonance imaging (fMRI) was used alongside a FEPT, depicting neutral, mildly happy and happy faces, to examine the neural correlates of implicit emotion processing in AN. Participants were instructed to specify the gender of the faces. Levels of depression, anxiety, obsessive–compulsive symptoms and eating disorder behaviour were obtained and principal component analysis (PCA) was performed to acquire uncorrelated variables. fMRI analysis revealed a greater blood-oxygenation level dependent (BOLD) response in AN in the right fusiform gyrus to all facial expressions. This response showed a linear increase with the happiness of the facial expression and was found to be stronger in those not taking medication. PCA analysis revealed a single component indicating a greater level of general clinical symptoms. Neuroimaging findings would suggest that alterations in implicit emotion processing in AN occur during early perceptual processing of social signals and illustrate greater engagement on the FEPT. The lack of separate components using PCA suggests that the questionnaires used might not be suited as predictive measures. Greater BOLD response in AN in the right fusiform gyrus to all facial expressions. The BOLD response showed a linear increase with the happiness of the expression The BOLD response was stronger in those not taking psychotropic medication These alterations occur during early perceptual processing of social signals
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影响因子：
10.6
作者：
Favaro, Angela;Santonastaso, Paolo;Di Salle, Francesco
通讯作者：
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DOI：
10.3109/00048674.2010.524625
发表时间：
2010-12-01
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