The shifting perspectives study protocol: Cognitive remediation therapy as an adjunctive treatment to family based treatment for adolescents with anorexia nervosa.
The shifting perspectives study protocol: Cognitive remediation therapy as an adjunctive treatment to family based treatment for adolescents with anorexia nervosa.
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DOI：
10.1016/j.cct.2021.106313
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发表时间：
2021-04
影响因子：
2.2
通讯作者：
Peebles R
中科院分区：
文献类型：
--
作者：
Timko CA;Bhattacharya A;Fitzpatrick KK;Howe H;Rodriguez D;Mears C;Heckert K;Ubel PA;Ehrenreich-May J;Peebles R
患有神经性厌食症的青少年具有设置转换的低效率，饥饿可能会加剧这种低效率，并且可能会干扰治疗干预的结果。认知补救疗法（CRT）是一种专注于改善定势转移的连续性治疗，可以针对低效，并可能提高治疗效果。将CRT添加到青少年厌食症标准治疗（家庭治疗，FBT）中的最佳方法仍有待研究。这是一项随机对照试验，旨在确定CRT是否能有效增加厌食症青少年和/或其父母的灵活性。参与者是12-18岁的厌食症青少年及其父母。54个家庭组将被随机分为三组之一：仅FBT组、FBT加以家长为中心的CRT组或FBT加以青少年为中心的CRT组。将在整个研究期间收集心理社会、神经认知和行为指标。这是首次将CRT应用于父母的研究。在厌食症的背景下，所有形式的CRT都针对具有厌食症思维方式的个体。我们认为，针对青少年厌食症患者的父母可能是有影响的，因为父母在FBT期间承担着治疗和重新营养孩子的负担，并且可能具有相似的思维方式。本研究采用实验治疗学的方法，以进一步了解青少年厌食症的治疗机制。它的重点是增加患者或其父母的认知灵活性，并确定实现积极变化所需的CRT的适当剂量。ClinicalTrials.gov标识符NCT 03928028
Adolescents with anorexia nervosa have set-shifting inefficiencies that can be exacerbated by starvation and that may interfere with outcomes of treatment interventions. Cognitive Remediation Therapy (CRT), an adjunctive treatment focused on improving set-shifting, can target inefficiencies and may augment treatment effectiveness. The best way to add CRT to the standard of care (Family Based Treatment, FBT) for adolescents with anorexia remains understudied. This is a randomized controlled trial designed to determine if CRT is effective in increasing flexibility in adolescents with anorexia and/or their parents. Participants are adolescents 12-18 years old with anorexia and their parents. 54 family groups will be randomized into one of three groups: FBT only, FBT plus Parent-focused CRT, or FBT plus Adolescent-focused CRT. Psychosocial, neurocognitive, and behavioral measures will be collected throughout the study. This is the first study of its kind to apply CRT to parents. All forms of CRT in the context of anorexia have targeted the individual with anorexia’s thinking style. We propose that it may be impactful to target the parent of the adolescent with anorexia as parents carry the burden of treatment and re-nourishment of their child during FBT and may have similar thinking styles. This study takes an experimental therapeutics approach to further our understanding of the mechanisms of treatment for adolescents with anorexia. It focuses on increasing cognitive flexibility in patients or their parents and determining the appropriate dose of CRT needed to achieve positive change. ClinicalTrials.gov Identifier NCT03928028
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影响因子：
2.5
作者：
Fluckiger, Christoph;Del Re, A. C.;Horvath, Adam O.
通讯作者：
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作者：
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