The Legacy of the TTASAAN Report - Premature Conclusions and Forgotten Promises About SPECT Neuroimaging: A Review of Policy and Practice Part II.
The Legacy of the TTASAAN Report - Premature Conclusions and Forgotten Promises About SPECT Neuroimaging: A Review of Policy and Practice Part II.
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DOI：
10.3389/fneur.2022.851609
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发表时间：
2022
影响因子：
3.4
通讯作者：
Cohen, Philip F.
中科院分区：
文献类型：
--
作者：
Pavel, Dan G.;Henderson, Theodore A.;DeBruin, Simon;Cohen, Philip F.
脑血流灌注单光子发射计算机断层扫描(SPECT)最初是在20世纪70年代发展起来的。一种关键的放射性药物--六亚甲基丙基亚胺肟(HMPAO)直到1993年才稳定下来，大多数早期的SPECT扫描都是在单头伽马相机上进行的。这些早期的扫描质量很差。1996年，美国神经病学学会(TTASAAN)治疗与技术评估小组委员会发布了一份关于SPECT在神经疾病评估中的应用的报告。这个由两部分组成的系列探讨了与SPECT功能神经成像相关的政策和程序。在第一部分中，介绍了在TTASAAN报告发表时SPECT扫描的质量以及关键神经和精神指征的数据深度与其间25年之间的比较。在第二部分，将探讨SPECT脑灌注成像和图像处理的技术方面。将回顾色标的作用，并介绍解释SPECT扫描的过程。对功能性脑扫描的解释不仅需要解剖学知识，还需要正确执行扫描的技术知识，而无论扫描方式如何。意识到技术上的局限性，使临床医生能够正确地解释功能性脑扫描。在此基础上，在四种情况下，SPECT灌注神经成像与其他成像方式和测试一起导致鉴别诊断的缩小和更好的治疗。最后，对现行政策和做法的修订提出了建议。
Brain perfusion single photon emission computed tomography (SPECT) scans were initially developed in 1970s. A key radiopharmaceutical, hexamethylpropyleneamine oxime (HMPAO), was not stabilized until 1993 and most early SPECT scans were performed on single-head gamma cameras. These early scans were of inferior quality. In 1996, the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology (TTASAAN) issued a report regarding the use of SPECT in the evaluation of neurological disorders. This two-part series explores the policies and procedures related to perfusion SPECT functional neuroimaging. In Part I, the comparison between the quality of the SPECT scans and the depth of the data for key neurological and psychiatric indications at the time of the TTASAAN report vs. the intervening 25 years were presented. In Part II, the technical aspects of perfusion SPECT neuroimaging and image processing will be explored. The role of color scales will be reviewed and the process of interpreting a SPECT scan will be presented. Interpretation of a functional brain scans requires not only anatomical knowledge, but also technical understanding on correctly performing a scan, regardless of the scanning modality. Awareness of technical limitations allows the clinician to properly interpret a functional brain scan. With this foundation, four scenarios in which perfusion SPECT neuroimaging, together with other imaging modalities and testing, lead to a narrowing of the differential diagnoses and better treatment. Lastly, recommendations for the revision of current policies and practices are made.
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影响因子：
4.7
作者：
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通讯作者：
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