Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City.
Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City.
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DOI：
10.1002/ijc.24454
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发表时间：
2009-09-15
影响因子：
6.4
通讯作者：
López-Carrillo L
中科院分区：
文献类型：
--
作者：
Hernández-Ramírez RU;Galván-Portillo MV;Ward MH;Agudo A;González CA;Oñate-Ocaña LF;Herrera-Goepfert R;Palma-Coca O;López-Carrillo L
n -亚硝基化合物（NOC）是强效的动物致癌物和潜在的人类致癌物。对大多数人来说，主要的接触源可能是内源性的，这一过程可以通过饮食中的多酚来抑制。为了估计胃癌（GC）的风险与多酚和NOC前体（硝酸盐和亚硝酸盐）的个体和联合消费有关，2004年至2005年在墨西哥城进行了一项基于人群的病例对照研究，其中包括257例组织学证实的GC病例和478例对照。多酚、硝酸盐和亚硝酸盐的摄入量通过食物频率问卷进行评估。高摄入量的肉桂酸、第二异核桃树脂醇和库美特醇与GC风险降低50%相关。总亚硝酸盐以及动物源的硝酸盐和亚硝酸盐的高摄入量使胃癌的风险增加了一倍。在低摄入肉桂酸、二异脂树脂醇或库美特醇和高摄入动物源性硝酸盐或亚硝酸盐的人群中，比值比分别为高摄入多酚和低摄入动物源性硝酸盐或亚硝酸盐的人群的2倍左右。肠型和弥漫性GC的结果相似。我们的研究结果首次表明，大量摄入肉桂酸、第二异脂树脂醇和库美特罗对胃癌有保护作用，并表明这些多酚通过抑制内源性亚硝化作用来降低胃癌风险。肉桂酸的主要来源是梨、芒果和豆类；豆类、胡萝卜和南瓜中含有第二异丙醇，豆类中含有甘豆醇。
N-Nitroso compounds (NOC) are potent animal carcinogens and potential human carcinogens. The primary source of exposure for most individuals may be endogenous formation, a process that can be inhibited by dietary polyphenols. To estimate the risk of gastric cancer (GC) in relation to the individual and combined consumption of polyphenols and NOC precursors (nitrate and nitrite), a population-based case–control study was carried out in Mexico City from 2004 to 2005 including 257 histologically confirmed GC cases and 478 controls. Intake of polyphenols, nitrate and nitrite were estimated using a food frequency questionnaire. High intakes of cinnamic acids, secoisolariciresinol and coumestrol were associated with an ~50% reduction in GC risk. A high intake of total nitrite as well as nitrate and nitrite from animal sources doubled the GC risk. Odds ratios around 2-fold were observed among individuals with both low intake of cinnamic acids, secoisolariciresinol or coumestrol and high intake of animal-derived nitrate or nitrite, compared to high intake of the polyphenols and low animal nitrate or nitrite intake, respectively. Results were similar for both the intestinal and diffuse types of GC. Our results show, for the first time, a protective effect for GC because of higher intake of cinnamic acids, secoisolariciresinol and coumestrol, and suggest that these polyphenols reduce GC risk through inhibition of endogenous nitrosation. The main sources of these polyphenols were pears, mangos and beans for cinnamic acids; beans, carrots and squash for secoisolariciresinol and legumes for coumestrol.
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影响因子：
2.3
作者：
Garcia-Closas, R;Gonzalez, CA;Riboli, E
通讯作者：
Riboli, E
DOI：
10.1016/0926-6917(94)90022-1
发表时间：
1994-11-01
期刊：
EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION
影响因子：
--
作者：
GANGOLLI, SD;VANDENBRANDT, PA;WISHNOK, JS
通讯作者：
WISHNOK, JS
DOI：
10.1111/apm.1965.64.1.31
发表时间：
1965-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
LAUREN, P
通讯作者：
LAUREN, P
影响因子：
7.1
作者：
Arts, ICW;Hollman, PCH
通讯作者：
Hollman, PCH
DOI：
10.1080/026520300412546
发表时间：
2003-07-01
期刊：
FOOD ADDITIVES AND CONTAMINANTS
影响因子：
--
作者：
Chung, SY;Kim, JS;Song, IS
通讯作者：
Song, IS