Impact of perinatal exposure to equol enantiomers on reproductive development in rodents.
Impact of perinatal exposure to equol enantiomers on reproductive development in rodents.
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DOI：
10.1016/j.reprotox.2011.05.008
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Setchell KD
中科院分区：
文献类型：
--
作者：
Brown NM;Lindley SL;Witte DP;Setchell KD
目前，人们对大豆代谢产物牛尿酚产生了相当大的兴趣，牛尿酚以对映体形式S-（-）牛尿酚和R-（+）牛尿酚存在，两者的生物学作用不同。对任一对映体对生殖发育的影响知之甚少，但由于最近S-（−）雌马酚作为膳食补充剂的商业化，这种知识是基本的。因此，研究了S-（−）雌马酚和R-（+）雌马酚，以确定其对Sprague-Dawley大鼠生殖发育和生育力的影响。两种对映异构体均不影响生育力、产窝数、每窝幼仔数、出生的雄性和雌性幼仔数、出生体重、肛门生殖器距离、睾丸下降或阴道开口。组织学分析显示，饮食接触S-（−）雌马酚或R-（+）雌马酚后，卵巢、睾丸、前列腺或精囊组织无重大异常，但两种对映体均引发子宫组织增生。对于R-（+）雌马酚，这种刺激作用在停止接触后消退，但S-（−）雌马酚的作用延长。
There is now considerable interest in the intestinally derived soy isoflavone metabolite, equol, which occurs in the enantiomeric forms, S-(−)equol and R-(+)equol, both differing in biological actions. Little is known about effects of either enantiomer on reproductive development, yet such knowledge is fundamental because of the recent commercialization of S-(−)equol as a dietary supplement. S-(−)equol and R-(+)equol were therefore investigated to determine their effects on reproductive development and fertility in the Sprague–Dawley rat. Neither enantiomer affected fertility, number of litters produced, number of pups per litter, number of male and female pups born, birth weight, anogenital distance, testicular descent or vaginal opening. Histological analysis showed no major abnormalities in ovary, testis, prostate or seminal vesicle tissue with dietary exposure to S-(−)equol or R-(+)equol, but both enantiomers triggered hyperplasia of uterine tissue. With R-(+)equol this stimulatory effect subsided after exposure was discontinued, but the effect of S-(−)equol was prolonged.
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DOI：
10.1111/j.1751-0813.1946.tb15473.x
发表时间：
1946-01-01
期刊：
AUSTRALIAN VET JOUR
影响因子：
--
作者：
Bennetts, H. W.;Underwood, E. J.;Shier, F. L.
通讯作者：
Shier, F. L.
影响因子：
6.1
作者：
Degen, GH;Janning, P;Bolt, HM
通讯作者：
Bolt, HM
影响因子：
4.7
作者：
Ju, Young H.;Allred, Kimberly F.;Helferich, William G.
通讯作者：
Helferich, William G.
影响因子：
3.8
作者：
Fuhrman, Barbara J.;Teter, Barbara E.;Muti, Paola C.
通讯作者：
Muti, Paola C.
影响因子：
3.6
作者：
FREY, HL;PENG, S;RAJFER, J
通讯作者：
RAJFER, J