Communication is key: extracellular vesicles as mediators of infection and defence during host-microbe interactions in animals and plants.
Communication is key: extracellular vesicles as mediators of infection and defence during host-microbe interactions in animals and plants.
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通讯是关键：在动物和植物的宿主-微生物相互作用中，细胞外囊泡作为感染和防御的介质。
DOI：
10.1093/femsre/fuab044
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发表时间：
2022-01-18
影响因子：
11.3
通讯作者：
Inal J
中科院分区：
文献类型：
--
作者：
U Stotz H;Brotherton D;Inal J
细胞外小泡(EV)现在被认为是细胞通讯的无处不在的媒介。在这篇综述中，我们认为EVS已经进化成一个高度调控的通讯系统，具有复杂的功能，包括废物、毒素和营养物质的输出，免疫效应器的靶向递送和RNA沉默的载体。真核EV有不同的形状和大小，并根据它们的生物发生和大小分布进行了分类。小的EV(或外体)通过内体来源的多囊体与质膜的融合而释放。中等EVS(或微泡)以胞吐作用的形式从质膜上萌发出来。最后，作为凋亡过程的结果，会产生大的EV(或凋亡小体)。这篇综述讨论了EV在四个真核生物王国中的分泌和摄取，其中三个王国产生细胞壁。讨论了细胞壁对植物和真菌中EVS的影响，以及真菌EVS在毒力中的作用。介绍了植物EV对发育和先天免疫的贡献。引人注目的案例是孢子体自交不亲和和吸器形成丝状病原体对细胞的入侵。考虑到EVS的进化史，EVS参与所有这些真核过程是一致的。在动物细胞外小泡(EVS)及其相互作用的背景下，植物和真菌EVS生长领域的最新发展表明，为了感染/保护，与微生物进行了复杂的跨王国交流。
Extracellular vesicles (EVs) are now understood to be ubiquitous mediators of cellular communication. In this review, we suggest that EVs have evolved into a highly regulated system of communication with complex functions including export of wastes, toxins and nutrients, targeted delivery of immune effectors and vectors of RNA silencing. Eukaryotic EVs come in different shapes and sizes and have been classified according to their biogenesis and size distributions. Small EVs (or exosomes) are released through fusion of endosome-derived multivesicular bodies with the plasma membrane. Medium EVs (or microvesicles) bud off the plasma membrane as a form of exocytosis. Finally, large EVs (or apoptotic bodies) are produced as a result of the apoptotic process. This review considers EV secretion and uptake in four eukaryotic kingdoms, three of which produce cell walls. The impacts cell walls have on EVs in plants and fungi are discussed, as are roles of fungal EVs in virulence. Contributions of plant EVs to development and innate immunity are presented. Compelling cases are sporophytic self-incompatibility and cellular invasion by haustorium-forming filamentous pathogens. The involvement of EVs in all of these eukaryotic processes is reconciled considering their evolutionary history. Within the context of animal extracellular vesicles (EVs) and their interactions, recent developments in the growing fields of plant and fungal EVs suggest complex cross-kingdom communication with microbes for infection/protection.
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DOI：
10.1038/nrmicro3480
发表时间：
2015-10
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Brown L;Wolf JM;Prados-Rosales R;Casadevall A
通讯作者：
Casadevall A
影响因子：
3.4
作者：
An, QL;Hückelhoven, R;Van Bel, AJE
通讯作者：
Van Bel, AJE
影响因子：
5.6
作者：
Bleackley, Mark;Samuel, Monisha;Anderson, Marilyn A.
通讯作者：
Anderson, Marilyn A.
DOI：
10.1126/science.aar4142
发表时间：
2018-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cai Q;Qiao L;Wang M;He B;Lin FM;Palmquist J;Huang SD;Jin H
通讯作者：
Jin H
影响因子：
14.9
作者：
Allain V;Bourgaux C;Couvreur P
通讯作者：
Couvreur P