Cardiovascular, renal, and endocrine responses in male quadriplegics during head-out water immersion.
Cardiovascular, renal, and endocrine responses in male quadriplegics during head-out water immersion.
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男性四肢瘫痪者头朝外浸水时的心血管、肾脏和内分泌反应。
DOI：
10.1152/ajpregu.1990.258.6.r1424
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Shiraki,K
中科院分区：
文献类型：
--
作者：
Tajima,F;Sagawa,S;Iwamoto,J;Miki,K;Freund,BJ;Claybaugh,JR;Shiraki,K
本研究通过比较四肢瘫痪者（QP）和正常人的生理反应来确定中枢神经系统的作用对浸水利尿机制的相对影响。禁食一夜后，7名完全颈髓横断（C5-C8）的男性QP受试者和6名正常男性在热中性水（34.5-35.0摄氏度）中头外浸泡（HOI）前、中、后3小时进行测试。QP受试者的尿流量和总尿量（3 h内309 ± 53 ml）的可逆性增加与正常受试者（3 h内318 ± 96 ml）相当。而渗透压排泄增加QP受试者，其幅度较小时，与正常人相比。相反，QP受试者尿流量增加的特征是肾小球滤过率（GFR）和游离水清除率增加，而正常受试者主要是渗透性利尿，GFR无变化。HOI仅在QP受试者中升高收缩压（P <0.05），而两组心输出量的增加相同。虽然QP受试者的血浆肾素活性和醛固酮对HOI的反应与正常人相当，但QP受试者的血浆心钠素（ANF）在HOI期间高出两倍（P <0.05），而QP受试者由于HOI而导致的ANF增加约3倍（P <0.05）与正常受试者相同。（250字处删节）
The present study was undertaken to determine the relative influence of the action of the central nervous system on the mechanism of water-immersion-induced diuresis by comparing physiological responses of quadriplegic (QP) and normal subjects. After overnight fasting seven male QP subjects with complete cervical cord transections (C5-C8) and six normal men were tested before, during, and after 3 h of head-out immersion (HOI) in thermoneutral water (34.5-35.0 degrees C). The reversible increase in urine flow and the total urine volume (309 +/- 53 ml in 3 h) in QP subjects were comparable with that of the normal subjects (318 +/- 96 ml in 3 h). While osmolal excretion was increased in QP subjects, its magnitude was less when compared with that of normal subjects. Instead, the increased urine flow in QP subjects was characterized by increased glomerular filtration rate (GFR) and free water clearance, in contrast to a predominantly osmotic diuresis with no changes in GFR in the normal subjects. The HOI elevated (P less than 0.05) systolic pressure only in QP subjects, whereas the increase in cardiac output was the same in both groups. While plasma renin activity and aldosterone responses to HOI in QP subjects were comparable with those of normal individuals, plasma atrial natriuretic factor (ANF) in QP subjects was twofold higher (P less than 0.05) during HOI, and the approximately threefold increase in ANF (P less than 0.05) in QP subjects due to HOI was the same as that of normal subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
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影响因子：
6
作者：
Thomas A. Pearson;E. C. Kramer;Kim Solez;R. Heptinstall
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DOI：
--
发表时间：
1980
期刊：
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影响因子：
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DOI：
10.1016/s0021-9258(17)33205-2
发表时间：
1976-08
期刊：
The Journal of biological chemistry
影响因子：
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作者：
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DOI：
10.1017/s0016672300016104
发表时间：
1975
期刊：
Genetical research
影响因子：
--
作者：
B. Taylor;H. Meier
通讯作者：
H. Meier
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影响因子：
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作者：
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通讯作者：
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