Abdominal adipose tissue radiodensity is associated with survival after colorectal cancer.
Abdominal adipose tissue radiodensity is associated with survival after colorectal cancer.
复制标题
DOI：
10.1093/ajcn/nqab285
复制
发表时间：
2021-12-01
期刊：
影响因子：
--
通讯作者：
Caan BJ
中科院分区：
文献类型：
--
作者：
Feliciano EMC;Winkels RM;Meyerhardt JA;Prado CM;Afman LA;Caan BJ
脂肪组织放射密度可能对结直肠癌（CRC）的生存具有重要的预后意义。较低的放射密度指示较大的脂肪细胞，而较高的放射密度可能代表脂肪细胞萎缩、炎症或水肿。我们研究了非转移性结直肠癌患者脂肪组织放射密度和脂肪组织放射密度纵向变化与死亡率的关系。在3023例I-III期CRC患者中，从诊断性计算机断层扫描（CT）图像中定量内脏脂肪组织（VAT）和皮下脂肪组织（SAT）的放射密度。有1775例患者的随访图像可用。考克斯比例风险模型和限制性三次样条用于检查诊断值和纵向变化的VAT和SAT放射密度与死亡风险的相关性，调整了潜在的混杂因素，包括身体大小和合并症。VAT和SAT放射密度与全因死亡率呈线性相关：VAT放射密度每SD增加的死亡HR为1.21（95% CI，1.11-1.32），SAT放射密度为1.18（95% CI，1.11-1.26）。脂肪组织放射密度的变化与死亡风险呈曲线相关。VAT放射密度增加至少1个SD的HR为1.53（95% CI，1.23-1.90），而与维持放射密度在基线的1个SD内相比，VAT放射密度降低至少1个SD的HR为1.11（95% CI，0.84-1.47），无显著性。同样，与放射密度无变化相比，SAT放射密度增加（HR，1.88; 95% CI，1.48-2.40）而非降低（HR，1.20; 95% CI，0.94-1.54）显著增加死亡风险。在非转移性结直肠癌患者中，脂肪组织放射密度是总死亡率的一个新的危险因素，与BMI和体重变化无关。
Adipose tissue radiodensity may have prognostic importance for colorectal cancer (CRC) survival. Lower radiodensity is indicative of larger adipocytes, while higher radiodensity may represent adipocyte atrophy, inflammation, or edema. We investigated associations of adipose tissue radiodensity and longitudinal changes in adipose tissue radiodensity with mortality among patients with nonmetastatic CRC. In 3023 patients with stage I–III CRC, radiodensities of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were quantified from diagnostic computed tomography (CT) images. There were 1775 patients with follow-up images available. Cox proportional hazards models and restricted cubic splines were used to examine associations of at-diagnosis values and of longitudinal changes in VAT and SAT radiodensities with risks of death after adjusting for potential confounders, including body size and comorbidities. VAT and SAT radiodensities were linearly associated with all-cause mortality: the HRs for death per SD increase were 1.21 (95% CI, 1.11–1.32) for VAT radiodensity and 1.18 (95% CI, 1.11–1.26) for SAT radiodensity. Changes in adipose tissue radiodensity had curvilinear associations with risks of death. The HR for an increase in VAT radiodensity of at least 1 SD was 1.53 (95% CI, 1.23–1.90), while the HR for a decrease of at least 1 SD was nonsignificant at 1.11 (95% CI, 0.84–1.47) compared with maintaining radiodensity within 1 SD of baseline. Similarly, increases (HR, 1.88; 95% CI, 1.48–2.40) but not decreases (HR, 1.20; 95% CI, 0.94–1.54) in SAT radiodensity significantly increased the risk of death compared with no change in radiodensity. In patients with nonmetastatic CRC, adipose tissue radiodensity is a novel risk factor for total mortality that is independent of BMI and changes in body weight.
登录
查看更多内容
DOI：
10.1016/j.numecd.2015.12.002
发表时间：
2016-02-01
影响因子：
3.9
作者：
Shah, Ravi V.;Allison, M. A.;Murthy, V. L.
通讯作者：
Murthy, V. L.
DOI：
10.1007/s00432-018-2736-z
发表时间：
2018-11-01
影响因子：
3.6
作者：
van Baar, Harm;Beijer, S.;Winkels, R. M.
通讯作者：
Winkels, R. M.
影响因子：
5.9
作者：
Veld, Joyce;Vossen, Josephina A.;Bredella, Miriam A.
通讯作者：
Bredella, Miriam A.
影响因子：
3.3
作者：
Shen, W;Punyanitya, M;Heshka, S
通讯作者：
Heshka, S
DOI：
10.1097/spc.0b013e328331124a
发表时间：
2009-12-01
影响因子：
2.1
作者：
Prado, Carla M M;Birdsell, Laura A;Baracos, Vickie E
通讯作者：
Baracos, Vickie E