HIV treatment, antiretroviral adherence and AIDS mortality in people who inject drugs: a scoping review.
HIV treatment, antiretroviral adherence and AIDS mortality in people who inject drugs: a scoping review.
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DOI：
10.1093/eurpub/ckad008
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发表时间：
2023-06-01
影响因子：
4.4
通讯作者：
Des Jarlais, Don C.
中科院分区：
文献类型：
--
作者：
Uuskula, Anneli;Feelemyer, Jonathan;Des Jarlais, Don C.
注射吸毒者是艾滋病毒感染预防和护理的关键人群。这一范围审查涵盖了最近（2010年后）对PWID在艾滋病毒护理的连续阶段（从吸收到实现病毒抑制，再到避免艾滋病相关死亡）的参与进行的系统性审查。我们发现，参与PWID到抗逆转录病毒治疗（ART）的数据是特别稀缺，但一般表示在ART的参与度非常低。研究的依从性和实现病毒抑制显示出不同的结果，与PWID有时做其他患者群体。这一人群的社会、医疗和精神残疾的严重性对治疗提出了重大挑战，并导致艾滋病死亡率在艾滋病感染者和其他人群之间存在明显差距。鉴于存在多层次的障碍，在许多地方将难以实现艾滋病患者抗逆转录病毒疗法的当前目标（艾滋病规划署的快速通道目标，即95-95-95）。我们建议优先考虑降低HIV血清阳性PWID将HIV传播给他人的可能性，并降低HIV感染和其他合并症的发病率和死亡率。
People who inject drugs (PWID) are a key population for the prevention and care of HIV infection. This scoping review covers recent (post-2010) systematic reviews on engagement of PWID in sequential stages of HIV care from uptake, to achieving viral suppression, and to avoiding AIDS-related mortality. We found that data on engagement of PWID into antiretroviral therapy (ART) were particularly scarce, but generally indicated very low engagement in ART. Studies of adherence and achieving viral suppression showed varying results, with PWID sometimes doing as well as other patient groups. The severity of social, medical and psychiatric disability in this population poses significant treatment challenges and leads to a marked gap in AIDS mortality between PWID and other population groups. Given the multi-level barriers, it will be difficult to reach current targets (UNAIDS fast-track targets of 95–95–95) for ART for PWID in many locations. We suggest giving priority to reducing the likelihood that HIV seropositive PWID will transmit HIV to others and reducing morbidity and mortality from HIV infection and from other comorbidities.
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影响因子：
4.2
作者：
McNamara KF;Biondi BE;Hernández-Ramírez RU;Taweh N;Grimshaw AA;Springer SA
通讯作者：
Springer SA
在过渡，低收入国家注射药物的人中遵守抗逆转录病毒药物：国际系统审查。
影响因子：
4.4
作者：
Feelemyer, Jonathan;Des Jarlais, Don;Arasteh, Kamyar;Uuskula, Anneli
通讯作者：
Uuskula, Anneli
影响因子：
4.2
作者：
Glick JL;Huang A;Russo R;Jivapong B;Ramasamy V;Rosman L;Pelaez D;Footer KHA;Sherman SG
通讯作者：
Sherman SG
影响因子：
5
作者：
Genberg, Becky L.;Kirk, Gregory D.;Mehta, Shruti H.
通讯作者：
Mehta, Shruti H.
影响因子：
4.4
作者：
Des Jarlais, Don C.;Duong Thi Huong;Nagot, Nicolas
通讯作者：
Nagot, Nicolas