3D printed tablets with internal scaffold structure using ethyl cellulose to achieve sustained ibuprofen release
3D printed tablets with internal scaffold structure using ethyl cellulose to achieve sustained ibuprofen release
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使用乙基纤维素3D打印具有内部支架结构的片剂以实现布洛芬的持续释放
DOI：
10.1016/j.ejps.2018.01.005
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发表时间：
2018-03
影响因子：
4.6
通讯作者：
Gensheng Yang
中科院分区：
文献类型：
--
作者：
Yan Yang;Huihui Wang;Haichao Li;Zhimin Ou;Gensheng Yang
本研究的目的是使用3D打印制备和评估具有预先设计的内部支架结构的片剂，以实现药物的持续释放。将模型药物布洛芬和缓释材料乙基纤维素与其他辅料混合，通过热熔挤出法挤出成丝。然后将这些获得的长丝通过熔融沉积成型印刷成片剂。片剂的印刷适性和药物释放行为受药物含量、释放调节剂、印刷参数和建模的影响。通过加入一定量的释药调节剂，调节模型的填充方式、填充密度和壳层厚度，使药物在24 h内释放最优化、最完全。通过扫描电子显微镜观察药物释放曲线和片剂完整性表明，药物从这些印刷片剂中通过扩散-侵蚀机制释放。所有结果都表明，3D打印是一种高度可调和数字可控的技术，可用于生产量身定制的药物。
The object of this study is to prepare and evaluate tablets with predesigned internal scaffold structure using 3D printing to achieve sustained drug release. Model drug (ibuprofen) and sustained release material (ethyl cellulose), together with other excipients, were firstly mixed and extruded into filaments by hot melt extrusion. Then these obtained filaments were printed into tablets by fused deposition modeling. The tablets printability and drug release behavior were influenced by drug content, release modifiers, printing parameters and modeling. An optimized and completed drug release within 24 h was achieved by adding certain amount of release modifiers and by adjusting the fill pattern, fill density and shell thickness of models. Drug release profiles and tablet integrity by scanning electron microscope indicated that drug released from these printed tablets through a diffusion-erosion mechanism. All results demonstrated that 3D printing is a highly adjustable and digitally controllable technology that can be applied to produce release-tailored medications.
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影响因子：
3.3
作者：
Yilan Zhang;Rui Luo;Yi Chen;X. Ke;D. Hu;Miaomiao Han
通讯作者：
Yilan Zhang;Rui Luo;Yi Chen;X. Ke;D. Hu;Miaomiao Han
DOI：
10.1016/j.ejpb.2008.02.025
发表时间：
2009-01-01
影响因子：
4.9
作者：
Quinten, Thomas;De Beer, Thomas;Remon, Jean Paul
通讯作者：
Remon, Jean Paul
影响因子：
5.8
作者：
Goyanes, Alvaro;Martinez, Pamela Robles;Gaisford, Simon
通讯作者：
Gaisford, Simon
影响因子：
3.8
作者：
De Brabander, C;Van den Mooter, G;Remon, JP
通讯作者：
Remon, JP
影响因子：
5.8
作者：
Jiaxiang Zhang;Xin Feng;H. Patil;R. Tiwari;M. Repka
通讯作者：
Jiaxiang Zhang;Xin Feng;H. Patil;R. Tiwari;M. Repka