The Stability, Sustained Release and Cellular Antioxidant Activity of Curcumin Nanoliposomes.
The Stability, Sustained Release and Cellular Antioxidant Activity of Curcumin Nanoliposomes.
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姜黄素纳米脂质体的稳定性、缓释及细胞抗氧化活性
DOI：
10.3390/molecules200814293
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发表时间：
2015-08-05
期刊：
影响因子：
--
通讯作者：
Liu CM
中科院分区：
文献类型：
--
作者：
Chen X;Zou LQ;Niu J;Liu W;Peng SF;Liu CM
姜黄素是一种多功能的天然药物，被认为是安全的。然而，由于其水溶性差、理化性质不稳定和生物利用度不足，极大地限制了其在食品和医药工业中的应用。纳米脂质体包封能显著提高姜黄素的溶解度和稳定性。姜黄素纳米脂质体具有良好的物理化学性质（包封率= 57.1，粒径= 68.1 nm，多分散指数= 0.246，zeta电位=-3.16 mV）。与游离姜黄素相比，姜黄素纳米脂质体对碱性pH和金属离子具有良好的稳定性，并且在4 °C下具有良好的储存稳定性。姜黄素纳米脂质体也表现出良好的缓释性能。与游离姜黄素相比，姜黄素纳米脂质体呈现出相等的细胞抗氧化活性，这主要归因于其较低的细胞摄取，如通过荧光显微镜和流式细胞仪检测到的。本研究为姜黄素纳米脂质体的进一步应用提供了理论和实践指导。
Curcumin is a multifunctional and natural agent considered to be pharmacologically safe. However, its application in the food and medical industry is greatly limited by its poor water solubility, physicochemical instability and inadequate bioavailability. Nanoliposome encapsulation could significantly enhance the solubility and stability of curcumin. Curcumin nanoliposomes exhibited good physicochemical properties (entrapment efficiency = 57.1, particle size = 68.1 nm, polydispersity index = 0.246, and zeta potential = −3.16 mV). Compared with free curcumin, curcumin nanoliposomes exhibited good stability against alkaline pH and metal ions as well as good storage stability at 4 °C. Curcumin nanoliposomes also showed good sustained release properties. Compared with free curcumin, curcumin nanoliposomes presented an equal cellular antioxidant activity, which is mainly attributed to its lower cellular uptake as detected by fluorescence microscopy and flow cytometry. This study provide theoretical and practical guides for the further application of curcumin nanoliposomes.
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