Manganese-metalloporphyrin (ATN-10) as a tumor-localizing agent: magnetic resonance imaging and inductively coupled plasma atomic emission spectroscopy study with experimental brain tumors.
Manganese-metalloporphyrin (ATN-10) as a tumor-localizing agent: magnetic resonance imaging and inductively coupled plasma atomic emission spectroscopy study with experimental brain tumors.
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锰金属卟啉（ATN-10）作为肿瘤定位剂：磁共振成像和电感耦合等离子体原子发射光谱研究实验性脑肿瘤。
DOI：
10.1097/00006123-199905000-00130
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发表时间：
1998
期刊：
影响因子：
4.8
通讯作者：
G. Marchal
中科院分区：
文献类型：
--
作者：
Y. Ni;Y. Miao;W. Semmler;G. Marchal
目的：我们研究了一种新的锰金属卟啉（ATN-10）的选择性肿瘤蓄积是否发生在Fisher大鼠脑内9 L胶质瘤。方法：在静脉内施用ATN-10后，对具有肿瘤或非肿瘤血管源性脑水肿的脑进行磁共振成像。通过电感耦合等离子体原子发射光谱法测量组织锰浓度，直到ATN-10给药后48小时，以评价其在肿瘤、正常脑和肿瘤周围脑组织中的摄取。研究结果：在磁共振成像扫描中，ATN-10给药后5分钟，在肿瘤组织和非肿瘤血管源性脑水肿区域均观察到早期增强。然而，静脉注射ATN-10后24小时，仅在肿瘤组织中观察到延迟增强。大鼠脑标本和24小时磁共振成像扫描的比较显示，只有肿瘤的活性部分与ATN-10增强，坏死区域和区域的瘤周脑组织和非肿瘤血管源性水肿没有。在24小时，与正常和肿瘤周围脑组织相比，在肿瘤样品中发现ATN-10的显著更大的摄取。在24小时达到高肿瘤/正常脑组织比（10.4）。结论：ATN-10是一种锰-金属卟啉，是一种潜在有用的肿瘤定位剂，其积累并优先保留在活的肿瘤组织中。
OBJECTIVE: We examined whether selective tumor accumulation of a novel manganese-metalloporphyrin (ATN-10) occurs in Fisher rats bearing intracerebral 9L gliomas. METHODS: After intravenous administration of ATN-10, magnetic resonance imaging of brains with tumors or nontumoral vasogenic brain edema was performed. Tissue manganese concentrations were measured by inductively coupled plasma atomic emission spectroscopy until 48 hours after administration of ATN-10, to evaluate its uptake in tumor, normal brain, and peritumoral brain tissue. RESULTS: In magnetic resonance imaging scans, early enhancement was observed in both tumor tissue and regions of nontumoral vasogenic brain edema at 5 minutes after ATN-10 administration. However, delayed enhancement was noted only in tumor tissue, at 24 hours after intravenous injection of ATN-10. Comparison of rat brain specimens and 24-hour magnetic resonance imaging scans revealed that only the viable portions of tumors were enhanced with ATN-10; necrotic regions and areas of peritumoral brain tissue and nontumoral vasogenic edema were not. Significantly greater uptake of ATN-10 was found in tumor samples, compared with normal and peritumoral brain tissue, at 24 hours. A high tumor/normal brain tissue ratio (10.4) was achieved at 24 hours. CONCLUSION: ATN-10, a manganese-metalloporphyrin, is a potentially useful tumor-localizing agent that accumulates and is preferentially retained in viable tumor tissue.
影响因子：
5.8
作者：
Kessel,D
通讯作者：
Kessel,D
金属卟啉在磁共振成像中增强肿瘤的对比度。
影响因子：
6.7
作者：
Ogan,MD;Revel,D;Brasch,RC
通讯作者：
Brasch,RC
钆 (III) 泰克萨菲林复合物的临床前评估。
影响因子：
6.7
作者：
Young,SW;Sidhu,MK;Qing,F;Muller,HH;Neuder,M;Zanassi,G;Mody,TD;Hemmi,G;Dow,W;Mutch,JD
通讯作者：
Mutch,JD