Linking glycemic control and executive function in rural older adults with diabetes mellitus.
Linking glycemic control and executive function in rural older adults with diabetes mellitus.
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DOI：
10.1111/j.1532-5415.2010.02857.x
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发表时间：
2010-06
影响因子：
6.3
通讯作者：
Quandt SA
中科院分区：
文献类型：
--
作者：
Nguyen HT;Grzywacz JG;Arcury TA;Chapman C;Kirk JK;Ip EH;Bell RA;Quandt SA
研究血糖控制和认知执行功能领域之间的关系，并确定可能解释这种关系的血糖控制不佳的风险因素。横断面研究。在参与者家中进行的面对面访谈。来自北卡罗来纳州中南部三个县的95名患有糖尿病的农村老年人，包括非洲裔美国人、美洲印第安人和白人。参与者接受了统一的评估。使用经验证的方法评估糖皮质激素控制，并使用先前建立的一组测量和评分程序评估执行功能。获得有关糖尿病治疗药物、糖尿病知识和糖尿病自我护理行为的信息。在调整性别、年龄、教育、种族、糖尿病病程和抑郁症状的线性回归模型中，执行功能与血糖控制显著相关。执行功能评分高1分与A1C值低0.47相关（p < 0.01）。当控制几个血糖控制风险因素（包括糖尿病药物的使用和糖尿病知识）时，血糖控制与执行功能的相关性变得边缘显著（p值= 0.08）。这些结果表明，血糖控制不良与执行功能综合指标的表现受损相关，这种关系可能是由血糖控制的可改变风险因素（如使用糖尿病药物和糖尿病知识）解释的。
To examine the association between glycemic control and the executive functioning domain of cognition, and to identify risk factors for inadequate glycemic control that may explain this relation. Cross-sectional study. In-person interviews conducted in participants’ homes. Ninety-five rural older adults with diabetes that included African Americans, American Indians, and whites from three counties in south central North Carolina. Participants underwent uniform evaluations. Glycemic control was assessed using a validated method, and executive function was assessed using a previously established set of measures and scoring procedure. Information pertaining to medication for diabetes treatment, knowledge of diabetes, and diabetes self-care behaviors were obtained. In linear regression models adjusting for gender, age, education, ethnicity, duration of diabetes, and depressive symptoms, executive function was significantly associated with glycemic control. A 1-point higher executive function score was associated with a 0.47 lower A1C value (p < 0.01). The association of glycemic control with executive function became marginally significant (p-value = 0.08) when controlling for several glycemic control risk factors, including use of diabetes medication and diabetes knowledge. These results suggest that poor glycemic control is associated with impairments in performance on composite measures of executive function, and that this relation may be explained by modifiable risk factors for glycemic control such as use of diabetes medication and diabetes knowledge.
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影响因子：
2.6
作者：
Nguyen, Ha T.;Evans, Michele K.;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
16.2
作者：
Fitzgerald, JT;Funnell, MM;Davis, WK
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Davis, WK
影响因子：
168.9
作者：
Turner, RC;Holman, RR;Ward, JD
通讯作者：
Ward, JD
影响因子：
4.2
作者：
Messier, C
通讯作者：
Messier, C
影响因子：
3.7
作者：
Mungas, Dan;Reed, Bruce R.;DeCarli, Charles
通讯作者：
DeCarli, Charles