3D-printed hydrogel particles containing PRP laden with TDSCs promote tendon repair in a rat model of tendinopathy.
3D-printed hydrogel particles containing PRP laden with TDSCs promote tendon repair in a rat model of tendinopathy.
复制标题
DOI：
10.1186/s12951-023-01892-5
复制
发表时间：
2023-06-03
影响因子：
10.2
通讯作者：
Liu, An
中科院分区：
文献类型：
--
作者：
Li, Congsun;Wang, Jie;Yang, Weinan;Yu, Kang;Hong, Jianqiao;Ji, Xiaoxiao;Yao, Minjun;Li, Sihao;Lu, Jinwei;Chen, Yazhou;Yan, Shigui;Wu, Haobo;Ma, Chiyuan;Yu, Xiaohua;Jiang, Guangyao;Liu, An
跟腱损伤后的长期慢性炎症是肌腱病的关键。富含血小板血浆(PRP)注射是治疗肌腱病的常用方法，对肌腱修复有积极作用。此外，肌腱衍生干细胞(TDSCs)是位于肌腱中的干细胞，在维持组织内稳态和损伤后修复方面发挥着重要作用。本研究采用基于投影的三维生物打印技术制备了含PRP/TDSCs的可注射明胶甲基丙烯酰基(GelMA)微粒(PRP-tDSC-GM)。结果表明，PRP-tDSC-GM可通过下调PI3K-AKT通路，促进TDSC的肌腱分化，减轻炎症反应，从而促进体内肌腱的结构和功能修复。网上版载有补充材料，可在10.1186/s12951-023-01892-5查阅。
Long-term chronic inflammation after Achilles tendon injury is critical for tendinopathy. Platelet-rich plasma (PRP) injection, which is a common method for treating tendinopathy, has positive effects on tendon repair. In addition, tendon-derived stem cells (TDSCs), which are stem cells located in tendons, play a major role in maintaining tissue homeostasis and postinjury repair. In this study, injectable gelatine methacryloyl (GelMA) microparticles containing PRP laden with TDSCs (PRP–TDSC–GM) were prepared by a projection-based 3D bioprinting technique. Our results showed that PRP–TDSC–GM could promote tendon differentiation in TDSCs and reduce the inflammatory response by downregulating the PI3K–AKT pathway, thus promoting the structural and functional repair of tendons in vivo. The online version contains supplementary material available at 10.1186/s12951-023-01892-5.
登录
查看更多内容
影响因子：
4.1
作者：
Giovanini, Allan Fernando;Deliberador, Tatiana Miranda;Urban, Cicero de Andrade
通讯作者：
Urban, Cicero de Andrade
影响因子：
7.5
作者：
Carvalho Ade M;Badial PR;Álvarez LE;Yamada AL;Borges AS;Deffune E;Hussni CA;Garcia Alves AL
通讯作者：
Garcia Alves AL
影响因子：
82.9
作者：
Bi, Yanming;Ehirchiou, Driss;Young, Marian F.
通讯作者：
Young, Marian F.
影响因子：
4.8
作者：
de Mos, Marieke;van der Windt, Anna E.;van Osch, Gerjo J. V. M.
通讯作者：
van Osch, Gerjo J. V. M.
DOI：
10.1177/0363546516637176
发表时间：
2016-08
期刊：
The American journal of sports medicine
影响因子：
--
作者：
Hudgens JL;Sugg KB;Grekin JA;Gumucio JP;Bedi A;Mendias CL
通讯作者：
Mendias CL