Application of sensing techniques to cellular force measurement.

Application of sensing techniques to cellular force measurement.
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DOI:
10.3390/s101109948
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发表时间:
2010
期刊:
Sensors (Basel, Switzerland)
影响因子:
--
通讯作者:
Wang JH
Wang JH
中科院分区:
其他
文献类型:
--
作者:
Li B;Wang JH

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细胞牵引力 (CTF) 是细胞产生并施加在细胞外基质或底层基质上的力。 CTF 的作用是维持细胞形状、实现细胞迁移以及生成和检测机械信号。因此,它们在许多基本生物过程中发挥着至关重要的作用,包括血管生成、炎症和伤口愈合。因此,仔细检查 CTF 可以更好地理解此类过程的细胞和分子机制。为此,多年来已经开发了各种用于 CTF 测量的力传感技术。本文将对这些传感技术进行简要回顾,并评论细胞力学和生物学研究对改进力传感技术的需求。
Cell traction forces (CTFs) are the forces produced by cells and exerted on extracellular matrix or an underlying substrate. CTFs function to maintain cell shape, enable cell migration, and generate and detect mechanical signals. As such, they play a vital role in many fundamental biological processes, including angiogenesis, inflammation, and wound healing. Therefore, a close examination of CTFs can enable better understanding of the cellular and molecular mechanisms of such processes. To this end, various force-sensing techniques for CTF measurement have been developed over the years. This article will provide a concise review of these sensing techniques and comment on the needs for improved force-sensing technologies for cell mechanics and biology research.
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