Segmental microvascular permeability in ischemia-reperfusion injury in rat lung.
Segmental microvascular permeability in ischemia-reperfusion injury in rat lung.
复制标题
大鼠肺缺血再灌注损伤的节段微血管通透性。
DOI：
10.1152/ajplung.1999.276.6.l958
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Taylor,AE
中科院分区：
文献类型：
--
作者：
Khimenko,PL;Taylor,AE
在大鼠肺缺血再灌注(I/R)模型上，用肺泡前、后毛细血管滤过系数(ml⋅min−1⋅cmH2O−1⋅100g−1)测定节段性微血管通透性。流动肺和非流动肺的Kfc值高度相关(r=0.98P&0.0001)。另一组肺在无流动状态下测量Kfc值，当气道压力增加到20cmH2O，动脉或静脉压增加到7-8cmH2O时，测量肺泡前和肺泡后的Kfc值。对照组全肺和肺泡后Kfc值分别为0.0225±0.001和0.0219±0.001 ml⋅min−1⋅cmH2O−1⋅100g−1，肺泡前通透性极小(0.00003±0.00005 ml⋅min−1⋅cmH2O−1⋅100 g−1)。I/R后Kfc增加10倍至0.2597±0.006 ml⋅min−1⋅cmH2O−1⋅100g−1，前肺泡Kfc增加至0.0677±0.003 ml⋅min−1⋅cmH2O−1⋅100 g−1，后牙槽Kfc增加至0.1354±0.008 ml⋅min−1⋅cmH2O−1⋅100 g−1(P均<0.05)。这些数据表明，正常的溶媒微血管通透性主要是肺泡后，在I/R损伤后，肺泡后(小静脉)通透性占总通透性的52%，而肺泡前和肺泡血管分别只占总Kfc的27%和23%。
Segmental microvascular permeabilities were measured using pre- and postalveolar vessel capillary filtration coefficient (Kfc) values (ml ⋅ min−1⋅ cmH2O−1⋅ 100 g−1) in isolated rat lungs subjected to ischemia-reperfusion (I/R). TotalKfcvalues measured in flowing and nonflowing lungs were highly correlated (r= 0.98,P< 0.0001).Kfcvalues were then measured in another group of lungs under no-flow conditions when airway pressure was increased to 20 cmH2O and either the arterial or venous pressure was elevated to 7–8 cmH2O to measure the prealveolar and postalveolarKfcvalues. Control total and postalveolarKfcvalues were 0.0225 ± 0.001 and 0.0219 ± 0.001 ml ⋅ min−1⋅ cmH2O−1⋅ 100 g−1, respectively, and the prealveolar permeability was extremely small (0.00003 ± 0.00005 ml ⋅ min−1⋅ cmH2O−1⋅ 100 g−1).Kfcvalues were again made in nonflowing lungs that had been subjected to 45 min of ischemia followed by 30 min of reperfusion. After I/R, the total membraneKfcincreased 10-fold to 0.2597 ± 0.006 ml ⋅ min−1⋅ cmH2O−1⋅ 100 g−1, the prealveolarKfcincreased to 0.0677 ± 0.003 ml ⋅ min−1⋅ cmH2O−1⋅ 100 g−1, and the postalveolarKfcincreased to 0.1354 ± 0.008 ml ⋅ min−1⋅ cmH2O−1⋅ 100 g−1(P< 0.05 for all I/R values). These data indicate that normal solvent microvascular permeability was predominantly postalveolar, and after I/R damage, the postalveolar (venular) permeability comprised 52% of the total, whereas the prealveolar and alveolar vessels comprised only 27 and 23%, respectively, of the totalKfc.
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