Effects of Malania oleifera Chun Oil on the Improvement of Learning and Memory Function in Mice.
Effects of Malania oleifera Chun Oil on the Improvement of Learning and Memory Function in Mice.
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DOI：
10.1155/2020/8617143
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Wu R;Zhong S;Ni M;Zhu X;Chen Y;Chen X;Zhang L;Chen J
Malania oleifera Chun & S.K. Lee 的果实因其种子含油量高（>60%），尤其是已知比例最高的神经酸（>55%）而备受医学追捧。研究目的。目的是探讨不同剂量的马拉尼亚油春油（MOC油）对小鼠学习记忆的影响，并评估额外的DHA海藻油和维生素E是否有助于MOC油改善学习记忆及其可能的机制。 小鼠口服相关药物30天后，进行行为学测试，并检测海马氧化应激参数（超氧化物歧化酶、丙二醛、谷胱甘肽过氧化物酶）和生化指标（乙酰胆碱、乙酰胆碱酯酶、胆碱乙酰转移酶）。 实验结果表明，行为实验中MOC油处理可显着改善小鼠模型的学习记忆，提高海马GSH-PX活性，降低MDA含量，特别是46.27mg/kg剂量时效果尤为明显。添加DHA和VE能更好地辅助MOC油改善学习记忆，其机制可能与抑制氧化应激、抑制AChE活性、增加ACh含量有关。 我们的结果表明 MOC 油治疗可以改善学习和记忆障碍。因此，我们认为MOC油是开发神经酸产品的潜在重要资源。
The fruits of Malania oleifera Chun & S. K. Lee have been highly sought after medically because its seeds have high oil content (>60%), especially the highest known proportion of nervonic acid (>55%). Objective of the Study. The objective was to explore the effects of different doses of Malania oleifera Chun oil (MOC oil) on the learning and memory of mice and to evaluate whether additional DHA algae oil and vitamin E could help MOC oil improve learning and memory and its possible mechanisms. After 30 days of oral administration of the relevant agents to mice, behavioral tests were conducted as well as detection of oxidative stress parameters (superoxide dismutase, malondialdehyde, and glutathione peroxidase) and biochemical indicators (acetylcholine, acetyl cholinesterase, and choline acetyltransferase) in the hippocampus. Experimental results demonstrated that MOC oil treatment could markedly improve learning and memory of mouse models in behavioral experiments and increase the activity of GSH-PX in hippocampus and reduce the content of MDA, especially the dose of 46.27 mg/kg. The addition of DHA and VE could better assist MOC oil to improve the learning and memory, and its mechanism may be related to the inhibition of oxidative stress and restrain the activity of AChE and also increase the content of ACh. Our results demonstrated that MOC oil treatment could improve learning and memory impairments. Therefore, we suggest that MOC oil is a potentially important resource for the development of nervonic acid products.
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影响因子：
3.6
作者：
Hasanein, Parisa;Far, Massoud Teimuri
通讯作者：
Far, Massoud Teimuri
影响因子：
4.2
作者：
Cecchini, T;Ciaroni, S;Del Grande, P
通讯作者：
Del Grande, P
影响因子：
2
作者：
Akoh, CC;Moussata, CO
通讯作者：
Moussata, CO
DOI：
10.1155/2016/6320586
发表时间：
2016
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Chen LE;Wu F;Zhao A;Ge H;Zhan H
通讯作者：
Zhan H
DOI：
10.1097/mpg.0000000000000864
发表时间：
2015-10-01
影响因子：
2.9
作者：
Hurtado, Jose A.;Iznaola, Carmen;Lara-Villoslada, Federico
通讯作者：
Lara-Villoslada, Federico