Adverse Pregnancy Outcomes in Endometriosis - Myths and Realities.
Adverse Pregnancy Outcomes in Endometriosis - Myths and Realities.
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DOI：
10.1007/s13669-020-00281-1
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发表时间：
2020-03
影响因子：
0.5
通讯作者：
Missmer SA
中科院分区：
文献类型：
--
作者：
Farland LV;Davidson S;Sasamoto N;Horne AW;Missmer SA
对于妇女和新生儿子宫内膜异位症的长期健康和共病状况的关注日益增加。本综述的目的是综合和讨论子宫内膜异位症和不良妊娠结局风险的文献现状。研究子宫内膜异位症和不良妊娠结局的方法学考虑包括比较人群的复杂性、子宫内膜异位症的定义、样本量、残留混杂因素和相互作用。目前关于子宫内膜异位症和不良妊娠结局的研究应谨慎解释。迄今为止，有证据表明子宫内膜异位症可能与异位妊娠、前置胎盘、早产和剖宫产的高风险相关。虽然一直观察到流产和死胎的相关性，但相对风险很小。患有子宫内膜异位症的孕妇可能有更高的风险发生某些不良妊娠结局，因此可能受益于额外的监测。然而，需要更多的研究来证实这些关联，并应重点确保研究具有内部和外部有效性，以及调查子宫内膜异位症表型差异的可能性。此外，未来的研究应侧重于了解潜在的关联机制，并更好地了解早期干预如何通过增加妊娠期间的监测或筛查来改善结局。
There is increasing interest in the long-term health and comorbid conditions associated with endometriosis for both women and neonates. The purpose of this review was to synthesize and discuss the current state of the literature investigating endometriosis and risk of adverse pregnancy outcomes. Methodologic considerations for studying endometriosis and adverse pregnancy outcomes include complexities regarding the comparison population, endometriosis definition, sample size, residual confounding, and interactions. The current research on endometriosis and adverse pregnancy outcomes should be interpreted cautiously. To date, evidence suggests that endometriosis may be associated with higher risk of ectopic pregnancy, placenta previa, preterm birth, and cesarean section. While an association with miscarriage and stillbirth has been consistently observed, the relative risk was small. Pregnant women with endometriosis may be at higher risk for certain adverse pregnancy outcomes and may therefore benefit from additional monitoring. However, additional research is needed to confirm these associations and should focus on ensuring studies have internal and external validity, as well as, investigate the potential for differences in endometriosis phenotypes. Moreover, future research should focus on understanding potential mechanisms of association and better understanding how early interventions, through increased monitoring or screening during pregnancy, may improve outcomes.
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DOI：
10.1093/humrep/dey269
发表时间：
2018-10-01
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Lalani S;Choudhry AJ;Firth B;Bacal V;Walker M;Wen SW;Singh S;Amath A;Hodge M;Chen I
通讯作者：
Chen I
影响因子：
7.2
作者：
Hoover, Karen W.;Tao, Guoyu;Kent, Charlotte K.
通讯作者：
Kent, Charlotte K.
影响因子：
5
作者：
Bodnar, LM;Ness, RB;Roberts, JM
通讯作者：
Roberts, JM
影响因子：
3.7
作者：
Harada T;Taniguchi F;Onishi K;Kurozawa Y;Hayashi K;Harada T;Japan Environment & Children’s Study Group
通讯作者：
Japan Environment & Children’s Study Group
影响因子：
6.7
作者：
Chandra, Anjani;Stephen, Elizabeth Hervey
通讯作者：
Stephen, Elizabeth Hervey