Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins.
Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins.
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DOI：
10.1016/j.virusres.2017.01.018
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发表时间：
2017-04-15
期刊：
影响因子：
5
通讯作者：
Reguera J
中科院分区：
文献类型：
--
作者：
Ferron F;Weber F;de la Torre JC;Reguera J
布尼亚病毒和沙粒病毒是重要的公共卫生威胁。布尼亚病毒和沙粒病毒的分子生物学、共同点和差异特征。 LACV L 蛋白结构对理解病毒 RNA 合成的意义。布尼亚病毒和沙粒病毒抗病毒药物的现状和未来前景。布尼亚病毒科和沙粒病毒科病毒家族包括大量对人类具有高致病性的病毒。它们是具有负链 RNA 基因组的有包膜病毒，分为三个（布尼亚病毒）或两个（沙粒病毒）片段。每个基因组片段都被病毒核蛋白（NP）和聚合酶（L 蛋白）包裹，形成功能性核糖核蛋白（RNP）复合物。病毒 RNP 为 L 蛋白进行 RNA 复制和基因转录的生物合成过程提供了必要的背景。数十年的研究使人们对这两个病毒家族的 RNA 合成（包括 RNA 复制和基因转录）的分子过程有了很好的了解。在这篇综述中，我们将对布尼亚病毒科和沙粒病毒科的分子生物学的共同特征和差异进行全面了解。我们还将描述迄今为止为这些病毒家族确定的蛋白质和蛋白质-RNA复合物的结构，主要关注L蛋白，并讨论它们对理解病毒RNP结构内病毒RNA复制和基因转录机制的影响，同时考虑这些过程发生的细胞环境。最后，我们将讨论这些结构发现对于开发治疗由布尼亚病毒科和沙粒病毒科成员引起的人类疾病的抗病毒药物的影响。
Bunyavirus and arenavirus are important public health threats. Bunyavirus and arenavirus molecular biology, common and differential features. Implications of LACV L protein structure for understanding viral RNA synthesis. Current state and future perspectives on bunya- and arenavirus antivirals. Bunyaviridae and Arenaviridae virus families include an important number of highly pathogenic viruses for humans. They are enveloped viruses with negative stranded RNA genomes divided into three (bunyaviruses) or two (arenaviruses) segments. Each genome segment is coated by the viral nucleoproteins (NPs) and the polymerase (L protein) to form a functional ribonucleoprotein (RNP) complex. The viral RNP provides the necessary context on which the L protein carries out the biosynthetic processes of RNA replication and gene transcription. Decades of research have provided a good understanding of the molecular processes underlying RNA synthesis, both RNA replication and gene transcription, for these two families of viruses. In this review we will provide a global view of the common features, as well as differences, of the molecular biology of Bunyaviridae and Arenaviridae. We will also describe structures of protein and protein-RNA complexes so far determined for these viral families, mainly focusing on the L protein, and discuss their implications for understanding the mechanisms of viral RNA replication and gene transcription within the architecture of viral RNPs, also taking into account the cellular context in which these processes occur. Finally, we will discuss the implications of these structural findings for the development of antiviral drugs to treat human diseases caused by members of the Bunyaviridae and Arenaviridae families.
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影响因子：
11.8
作者：
Charrel RN;Gallian P;Navarro-Mari JM;Nicoletti L;Papa A;Sánchez-Seco MP;Tenorio A;de Lamballerie X
通讯作者：
de Lamballerie X
影响因子：
4.5
作者：
Barr, John N.
通讯作者：
Barr, John N.
影响因子：
3.5
作者：
Boger, DL
通讯作者：
Boger, DL
影响因子：
6.8
作者：
Borden, KLB;Freemont, PS
通讯作者：
Freemont, PS
DOI：
10.3390/v8050143
发表时间：
2016-05-24
期刊：
Viruses
影响因子：
--
作者：
Albornoz A;Hoffmann AB;Lozach PY;Tischler ND
通讯作者：
Tischler ND