Emergence of Toscana virus in Europe.

Emergence of Toscana virus in Europe.
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DOI:
10.3201/eid1111.050869
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发表时间:
2005-11
影响因子:
11.8
通讯作者:
de Lamballerie X
de Lamballerie X
中科院分区:
医学2区
文献类型:
--
作者:
Charrel RN;Gallian P;Navarro-Mari JM;Nicoletti L;Papa A;Sánchez-Seco MP;Tenorio A;de Lamballerie X

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在南欧,托斯卡纳病毒是导致无菌性脑膜炎的三大主要原因之一。托斯卡纳病毒(TOSV)是一种节肢动物传播病毒,于1971年在意大利中部地区的Perniciosus白蚁体内首次发现。在旅行者中的许多病例报告以及在地中海地区进行的临床研究和流行病学研究表明,TOSV对中枢神经系统(CNS)有趋向性,是其流行国家脑膜炎和脑炎的主要原因。在意大利中部,TOSV是5-10月最常见的脑膜炎病因,远远超过肠道病毒。在其他北地中海国家,TOSV是温暖季节与脑膜炎有关的3种最流行的病毒之一。因此,TOSV必须被认为是一种新的病原体。在这里,我们回顾了TOSV在欧洲的流行病学,并确定了未来研究中应该解决的问题。尽管越来越多的证据表明TOSV在医学上的重要作用是一种新出现的CNS感染原因,但TOSV仍然是一种未被研究的病原体,很少有医生意识到它可能导致CNS感染。
In southern Europe, Toscana virus is one of the three leading causes of aseptic meningitis. Toscana virus (TOSV) is an arthropodborne virus first identified in 1971 from the sandfly Phlebotomus perniciosus in central Italy. Many case reports in travelers and clinical research and epidemiologic studies conducted around the Mediterranean region have shown that TOSV has a tropism for the central nervous system (CNS) and is a major cause of meningitis and encephalitis in countries in which it circulates. In central Italy, TOSV is the most frequent cause of meningitis from May to October, far exceeding enteroviruses. In other northern Mediterranean countries, TOSV is among the 3 most prevalent viruses associated with meningitis during the warm seasons. Therefore, TOSV must be considered an emerging pathogen. Here, we review the epidemiology of TOSV in Europe and determine questions that should be addressed in future studies. Despite increasing evidence of its major role in medicine as an emerging cause of CNS infections, TOSV remains an unstudied pathogen, and few physicians are aware of its potential to cause CNS infections.
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发表时间: 1976-01-01
影响因子: 3.3
作者:
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发表时间: 2005-03-01
期刊: VIROLOGY
影响因子: 3.7
作者:
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