Visual cortex organisation in a macaque monkey with macular degeneration.
Visual cortex organisation in a macaque monkey with macular degeneration.
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DOI：
10.1111/ejn.12349
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发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Smirnakis SM
中科院分区：
文献类型：
--
作者：
Shao Y;Keliris GA;Papanikolaou A;Fischer MD;Zobor D;Jägle H;Logothetis NK;Smirnakis SM
视野在早期视觉区域中被视网膜定位地表示。有人认为，当成年人初级视皮层（V1）被剥夺正常的视网膜输入，它是能够大规模的重组，病变投射区（LPZ）内的神经元被视觉驱动的输入从完整的视网膜区域。早期的功能性磁共振成像（fMRI）研究显示黄斑变性（MD）患者的LPZ边界内的活动范围> 1 cm，而最近的结果显示LPZ边界没有移动。在这里，我们使用功能磁共振成像群体感受野测量研究，第一次，一只猕猴与MD的视觉皮层组织，并将其与正常对照组进行比较。我们的研究结果表明，边界的V1 LPZ保持稳定，表明去传入区V1区的MD动物有有限的重组能力。有趣的是，非去传入V1体素的pRF大小略有增加（平均约20%），尽管这种影响似乎弱于以前的单单位记录报告。V2区也显示出有限的重组。值得注意的是，MD动物的V5/MT区域与在MD动物中保留的视野部分上刺激的对照相比显示出广泛的激活。此外，群体感受野大小分布在MD动物的V5/MT区中显著不同。综上所述，这些结果表明，V5/MT具有更高的潜力，MD后重组比早期的视觉皮层。
The visual field is retinotopically represented in early visual areas. It has been suggested that when adult primary visual cortex (V1) is deprived of normal retinal input it is capable of large-scale reorganization, with neurons inside the lesion projection zone (LPZ) being visually driven by inputs from intact retinal regions. Early functional magnetic resonance imaging (fMRI) studies in humans with macular degeneration (MD) report > 1 cm spread of activity inside the LPZ border, whereas recent results report no shift of the LPZ border. Here, we used fMRI population receptive field measurements to study, for the first time, the visual cortex organization of one macaque monkey with MD and to compare it with normal controls. Our results showed that the border of the V1 LPZ remained stable, suggesting that the deafferented area V1 zone of the MD animal has limited capacity for reorganization. Interestingly the pRF size of non-deafferented V1 voxels increased slightly (∼20% on average), although this effect appears weaker than that in previous single-unit recording reports. Area V2 also showed limited reorganization. Remarkably, area V5/MT of the MD animal showed extensive activation compared to controls stimulated over the part of the visual field that was spared in the MD animal. Furthermore, population receptive field size distributions differed markedly in area V5/MT of the MD animal. Taken together, these results suggest that V5/MT has a higher potential for reorganization after MD than earlier visual cortex.
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