Neural correlates of a Go/NoGo task with alcohol stimuli in light and heavy young drinkers.
Neural correlates of a Go/NoGo task with alcohol stimuli in light and heavy young drinkers.
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DOI：
10.1016/j.bbr.2014.08.039
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发表时间：
2014-11-01
影响因子：
2.7
通讯作者：
Stacy, Alan W.
中科院分区：
文献类型：
--
作者：
Ames, Susan L.;Wong, Savio W.;Bechara, Antoine;Cappelli, Christopher;Dust, Mark;Grenard, Jerry L.;Stacy, Alan W.
抑制过程与影响日常决策的行为控制高度相关。 Go/NoGo 任务是一项常见任务，用于挖掘在高级执行功能中重要的基本抑制过程。本研究评估了执行 Go/NoGo 任务期间反应抑制的神经相关性，其中 NoGo 信号或抑制控制测试由啤酒瓶图像组成。对年龄从 18 岁到 22 岁的 21 名重度饮酒者和 20 名轻度饮酒者进行了分组比较。在行为方面，使用 d-prime 评估的总体表现在轻度饮酒者中明显更好。在神经水平上，在 NoGo 试验中，与轻度饮酒者相比，重度饮酒者的右背外侧前额叶皮层、内侧额叶皮层和扣带回的活动明显更大。这些区域涉及信息的反射或控制处理。此外，在 NoGo 试验中，重度饮酒者的脑岛活动明显高于轻度饮酒者，这是一个与习惯回路有关的神经区域，与线索诱发的冲动和药物物理作用的情绪记忆有关。这些结果表明，饮酒较多的人可能经历了工作记忆需求的增加和抑制反应的控制努力，因为啤酒 NoGo 试验中酒精线索的显着性增强导致抑制控制较差，该试验也涉及岛介导的效应。
Inhibitory processes are highly relevant to behavioral control affecting decisions made daily. The Go/NoGo task is a common task used to tap basic inhibitory processes important in higher order executive functioning. The present study assessed neural correlates of response inhibition during performance of a Go/NoGo task in which NoGo signals or tests of inhibitory control consisted of images of beer bottles. Group comparisons were conducted between 21 heavy and 20 light drinkers, ranging in age from 18 to 22. Behaviorally, overall performance assessed with d-prime was significantly better among the lighter drinkers. On a neural level, the heavy drinkers showed significantly greater activity in the right dorsolateral prefrontal cortex, medial frontal cortex and cingulate relative to the light drinkers during the NoGo trials. These regions are implicated in reflective or control processing of information. Further, heavy drinkers showed significantly greater activity in the insula relative to light drinkers during NoGo trials, a neural region implicated in habit circuitry and tied to cue induced urges and emotional memories of physical effects of drugs. These results suggest that the heavier drinkers may have experienced increased working memory demand and control efforts to withhold a response due to poorer inhibitory control from enhanced salience of alcohol cues on the beer NoGo trials, which also engaged insula mediated effects.
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影响因子：
4.4
作者：
Beltz, Adriene M.;Gates, Kathleen M.;Engels, Anna S.;Molenaar, Peter C. M.;Pulido, Carmen;Turrisi, Robert;Berenbaum, Sheri A.;Gilmore, Rick O.;Wilson, Stephen J.
通讯作者：
Wilson, Stephen J.
影响因子：
3.6
作者：
Crews, Fulton Timm;Boettiger, Charlotte Ann
通讯作者：
Boettiger, Charlotte Ann
DOI：
10.1097/00000374-200102000-00023
发表时间：
2001-02-01
影响因子：
3.2
作者：
Bowden, SC;Crews, FT;Ambrose, ML
通讯作者：
Ambrose, ML
影响因子：
4.8
作者：
Bechara, A;Van der Linden, M
通讯作者：
Van der Linden, M
影响因子：
3.4
作者：
Finn, PR;Justus, A;Steinmetz, JE
通讯作者：
Steinmetz, JE