Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure.
Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure.
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DOI：
10.1002/brb3.1147
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发表时间：
2018-12
影响因子：
3.1
通讯作者：
Cassaday HJ
中科院分区：
文献类型：
--
作者：
Pezze MA;Marshall HJ;Cassaday HJ
损伤背侧海马，以及毒蕈碱乙酰胆碱拮抗剂东莨菪碱的治疗，会损害痕量条件反射。然而，海马内的毒蕈碱受体的作用很少受到关注。本研究采用蔗糖颗粒作为非条件刺激（US），检查了在食欲（2 vs. 10 s）微量条件反射程序中海马内输注东莨菪碱（30 µg/侧）的影响。在不同的装置中检查运动活性（LMA）。海马内东莨菪碱降低了对2 s微量条件刺激（CS）的反应。海马内东莨菪碱在2和10 s描记间期的刺激间间期（ISI）内同样抑制反应，但在试验间间期没有这种作用。当输送US时，反应也有一些总体降低;在10 s时显著，但在2 s描记间隔时不显著。在条件反应的消退试验中，无药物（CS后5 s）显示了与采集期间CS反应相似的结果模式。东莨菪碱组LMA增加。结果表明，非特异性的活动或动机的变化，以回应美国不能解释减少CS反应和ISI测量跟踪条件反射的减少。相反，本研究的发现指出了任务的关联方面在确定其对东莨菪碱作用的敏感性方面的重要性，这表明海马中的毒蕈碱受体是短期工作记忆的重要调节剂。
Trace conditioning is impaired by lesions to dorsal hippocampus, as well as by treatment with the muscarinic acetylcholine antagonist scopolamine. However, the role of muscarinic receptors within hippocampus has received little attention. The present study examined the effects of intra‐hippocampal infusion of scopolamine (30 µg/side) in an appetitive (2 vs. 10 s) trace conditioning procedure using sucrose pellets as the unconditioned stimulus (US). Locomotor activity (LMA) was examined in a different apparatus. Intra‐hippocampal scopolamine reduced responding to the 2 s trace conditioned stimulus (CS). Intra‐hippocampal scopolamine similarly depressed responding within the inter‐stimulus interval (ISI) at both 2 and 10 s trace intervals, but there was no such effect in the inter‐trial interval. There was also some overall reduction in responding when the US was delivered; significant at the 10 s but not at the 2 s trace interval. A similar pattern of results to that seen in response to the CS during acquisition was shown drug‐free (in the 5 s post‐CS) in the extinction tests of conditioned responding. LMA was increased under scopolamine. The results suggest that nonspecific changes in activity or motivation to respond for the US cannot explain the reduction in trace conditioning as measured by reduced CS responding and in the ISI. Rather, the findings of the present study point to the importance of associative aspects of the task in determining its sensitivity to the effects of scopolamine, suggesting that muscarinic receptors in the hippocampus are important modulators of short‐term working memory.
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DOI：
10.1016/j.euroneuro.2015.07.018
发表时间：
2015-11
期刊：
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
影响因子：
--
作者：
Pezze MA;Marshall HJ;Fone KC;Cassaday HJ
通讯作者：
Cassaday HJ
影响因子：
4.1
作者：
Cassaday, H. J.;Finger, B. C.;Horsley, R. R.
通讯作者：
Horsley, R. R.
影响因子：
2.7
作者：
Hunt, Pamela S.;Richardson, Rick
通讯作者：
Richardson, Rick
影响因子：
4.1
作者：
Kantini, E;Norman, C;Cassaday, HJ
通讯作者：
Cassaday, HJ
中央胆碱能神经元被增强反馈迅速招募。
影响因子：
64.5
作者：
Hangya B;Ranade SP;Lorenc M;Kepecs A
通讯作者：
Kepecs A