Four-year incidence and progression of diabetic retinopathy and macular edema: the Los Angeles Latino Eye Study.
Four-year incidence and progression of diabetic retinopathy and macular edema: the Los Angeles Latino Eye Study.
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DOI：
10.1016/j.ajo.2009.11.014
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发表时间：
2010-05
影响因子：
4.2
通讯作者：
Azen, Stanley P.
中科院分区：
文献类型：
--
作者：
Varma, Rohit;Choudhury, Farzana;Klein, Ronald;Chung, Jessica;Torres, Mina;Azen, Stanley P.
目的：评估成年拉美裔糖尿病患者中糖尿病视网膜病变黄斑水肿(ME)和临床显著黄斑水肿(CSME)的4年发病率和进展情况。一项以人口为基础的纵向研究，对居住在洛杉矶的4658名自我认同的拉美裔人(主要是墨西哥裔美国人)进行了基线(2000-2003年)和4年(2004-2008年)的检查。参与者接受了标准化的眼科检查。糖尿病视网膜病变(DR)和CSME的诊断采用改良的Airlie House分类方案对立体眼底照片进行分级。当按年龄和病程分层时，使用卡方检验和趋势检验来评估发病率的差异。DR、ME和CSME的4年发生率分别为34.0%(182/699)、5.4%(38/699)和7.2%(50/699)。与年龄较大和糖尿病病程较短的人相比，年轻人和糖尿病病程较长的人发生糖尿病视网膜病变的几率更高。糖尿病病程越长，ME的发生率越高(P=0.004)。38.9%(126/324)的糖尿病视网膜病变恶化/进展，14.0%(37/265)的糖尿病视网膜病变改善。从非增殖型(NPDR)进展到增殖型DR(PDR)和从NPDR进展到具有高危特征的PDR的比例分别为5.3%和1.9%。与非西班牙裔白人相比，拉丁裔DR的4年发病率和进展以及ME和CSME的发生率较高。这些发现支持确定和修改与这些长期并发症相关的危险因素的必要性。
To estimate the 4-year incidence and progression of diabetic retinopathy macular edema (ME), and clinically significant macular edema (CSME) among adult Latinos with diabetes mellitus. A population-based, longitudinal study of 4658 self-identified Latinos (primarily Mexican-Americans), residing in Los Angeles, examined at baseline (2000-2003) and at 4 years (2004-2008). Participants underwent a standardized ophthalmic examination. Diabetic retinopathy (DR) and CSME were detected by grading of stereoscopic fundus photographs using the Modified Airlie House classification scheme. Chi-square and trend tests were used to assess differences in incidence when stratifying by age and duration of diabetes. The 4-year incidence of DR, ME and CSME was 34.0% (182/535) and 5.4% (38/699) and 7.2% (50/699) respectively. Younger persons and those with longer duration of diabetes mellitus had a higher incidence on DR compared to those who were older and had shorter duration of diabetes mellitus. A higher incidence of ME was associated with longer duration of diabetes mellitus (P=0.004). Worsening/Progression of any DR was found in 38.9% (126/324) and improvement occurred in 14.0% (37/265) of participants. Progression from non-proliferative (NPDR) to proliferative DR (PDR) and from NPDR to PDR with high-risk characteristics occurred in 5.3% and 1.9% of participants. The 4-year incidence and progression of DR and the incidence of ME and CSME among Latinos are high compared to non-Hispanic Whites. These findings support the need to identify and modify risk factors associated with these long-term complications.
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影响因子：
13.7
作者：
Varma, R;Paz, SH;Preston-Martin, S
通讯作者：
Preston-Martin, S
影响因子：
7.7
作者：
HAMMAN, RF;MAYER, EJ;BAXTER, J
通讯作者：
BAXTER, J
影响因子：
--
作者：
KLEIN, R;KLEIN, BEK;CRUICKSHANKS, KJ
通讯作者：
CRUICKSHANKS, KJ
影响因子：
13.7
作者：
Klein, R;Klein, BEK;Cruickshanks, KJ
通讯作者：
Cruickshanks, KJ
影响因子：
16.2
作者：
West, SK;Klein, R;Snyder, R
通讯作者：
Snyder, R